Sesquiterpenoid Tropolone Glycosides from Liriosma ovata

Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-02, Vol.78 (2), p.315-319
Main Authors: Ma, Jun, Pawar, Rahul S, Grundel, Erich, Mazzola, Eugene P, Ridge, Clark D, Masaoka, Takashi, Le Grice, Stuart F. J, Wilson, Jennifer, Beutler, John A, Krynitsky, Alexander J
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid - methods
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Olacaceae - chemistry
Peru
Plant Roots - chemistry
Ribonuclease H - antagonists & inhibitors
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Tropolone - analogs & derivatives
Tropolone - chemistry
Tropolone - isolation & purification
Tropolone - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography–quadrupole-orbital ion trap mass spectrometric (UHPLC–Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.
ISSN:0163-3864
1520-6025
DOI:10.1021/np5006696