Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay

Abstract Talaromyces marneffei causes fatal invasive mycosis in Southeast Asia. Diagnosis by culture has limited sensitivity and can result in treatment delay. We describe the use of a novel Mp1p enzyme immunoassay (EIA) to identify blood culture–negative talaromycosis, subsequently confirmed by bon...

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Bibliographic Details
Published in:Open forum infectious diseases 2020-11, Vol.7 (11), p.ofaa502-ofaa502
Main Authors: Ly, Vo Trieu, Thanh, Nguyen Tat, Thu, Nguyen Thi Mai, Chan, Jasper, Day, Jeremy N, Perfect, John, Nga, Cao Ngoc, Vinh Chau, Nguyen Van, Le, Thuy
Format: Article
Language:English
Subjects:
Antifungal agents
Antigens
Blood
Bone marrow
Brief Reports
Efavirenz
Health aspects
HIV patients
Imipenem
Immunotherapy
Infection
Medical examination
Mycoses
Rankings
Transplantation
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Summary:Abstract Talaromyces marneffei causes fatal invasive mycosis in Southeast Asia. Diagnosis by culture has limited sensitivity and can result in treatment delay. We describe the use of a novel Mp1p enzyme immunoassay (EIA) to identify blood culture–negative talaromycosis, subsequently confirmed by bone marrow cultures. This EIA has the potential to speed diagnosis, enabling early therapy initiation.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa502