Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species, such as and , used to treatment of gastrointestinal diseases. Pharmacological studies report its anti-inflammatory, antioxidant, and antinociceptive activity. To investigate antidiarrheal activity related to gastroint...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2020-11, Vol.26 (43), p.6795-6809
Main Authors: Pessoa, Michelle Liz de Souza, Silva, Leiliane Macena Oliveira, Araruna, Maria Elaine Cristina, Serafim, Catarina Alves de Lima, Júnior, Edvaldo Balbino Alves, Silva, Alessa Oliveira, Pessoa, Matheus Marley Bezerra, Neto, Hermes Diniz, Lima, Edeltrudes de Oliveira, Batista, Leônia Maria
Format: Article
Language:English
Subjects:
Antidiarrheals - pharmacology
Antidiarrheals - therapeutic use
Antifungal Agents - pharmacology
Antifungal Agents - therapeutic use
Basic Study
Camphanes
Diarrhea - chemically induced
Diarrhea - drug therapy
Gastrointestinal Motility
Humans
Models, Theoretical
Norbornanes
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species, such as and , used to treatment of gastrointestinal diseases. Pharmacological studies report its anti-inflammatory, antioxidant, and antinociceptive activity. To investigate antidiarrheal activity related to gastrointestinal motility, intestinal secretion and antimicrobial activity. A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity. Intestinal transit and gastric emptying protocols were used to assess a possible antimotility effect. Muscarinic receptors, presynaptic α -adrenergic and tissue adrenergic receptors, K channels, nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms. The antimicrobial activity was evaluated in the minimum inhibitory concentration model, the fractional inhibitory concentration index using the (-)-fenchone association method with standard antifungal agents. (-)-Fenchone (75, 150 and 300 mg/kg) showed antidiarrheal activity, with a significant decrease in the evacuation index. This activity is possibly related to a percentage of reduced intestinal transit (75, 150 and 300 mg/kg). The antimotility effect of (-)-fenchone decreased in the presence of pilocarpine, yohimbine, propranolol, L-NG-nitroarginine methyl ester or glibenclamide. In the enteropooling model, no reduction in intestinal fluid weight was observed. (-)- Fenchone did not show antibacterial activity; on the other hand, inhibits the growth of strains of fungi with a minimum fungicide concentration of 32 μg/mL. However, when it was associated with amphotericin B, no synergism was observed. The antidiarrheal effect of (-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms. (-)-Fenchone presents antifungal activity; however, it did not show antibacterial activity.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v26.i43.6795