Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid 19

Recent studies show that obesity is a risk factor for hospital admission and for critical care need in patients with coronavirus disease 2019 (COVID-19). The aim was to determine whether obesity is a risk factor for unfavourable health outcomes in patients affected by COVID-19 admitted to ICU. 95 co...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2021-03, Vol.31 (3), p.762-768
Main Authors: Rossi, Andrea P., Gottin, Leonardo, Donadello, Katia, Schweiger, Vittorio, Nocini, Riccardo, Taiana, Matteo, Zamboni, Mauro, Polati, Enrico
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
APACHE
Body Mass Index
COVID-19
COVID-19 - epidemiology
COVID-19 - mortality
Critical Illness
Female
Hospitalization - statistics & numerical data
Humans
Intensive care unit
Intensive Care Units
Length of Stay - statistics & numerical data
Male
Middle Aged
Obesity
Obesity - epidemiology
Obesity - mortality
Proportional Hazards Models
Risk Factors
SARS-CoV-2
Severity of Illness Index
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Summary:Recent studies show that obesity is a risk factor for hospital admission and for critical care need in patients with coronavirus disease 2019 (COVID-19). The aim was to determine whether obesity is a risk factor for unfavourable health outcomes in patients affected by COVID-19 admitted to ICU. 95 consecutive patients with COVID-19 (78 males and 18 females) were admitted to ICU and included in the study. Height, weight, BMI, Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, CRP, CPK, ICU and hospital length of stay and comorbidities were evaluated. Participants with obesity had a lower 28 day survival rate from ICU admission than normal weight subjects. Cox proportional hazard model-derived estimates, adjusted for age, gender and comorbidity, confirmed the results of the survival analysis (HR:5.30,95%C.I.1.26–22.34). Obese subjects showed longer hospital and ICU stay as compared with normal weight counterpart.Subjects with obesity showed significantly higher CRP and CPK levels than normal weight subjects. In individuals with obesity, careful management and prompt intervention in case of suspected SARS-CoV-2 infection is necessary to prevent the progression of the disease towards severe outcomes and the increase of hospital treatment costs. •Subjects with obesity showed a 5 times higher risk of in-hospital mortality.•Moreover they showed longer hospital stay.•During the first 7 days in ICU, subjects with obesity showed increased CRP levels.•During the first 7 days in ICU, subjects with obesity showed CPK levels.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2020.11.012