Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine

INTRODUCTIONMultiple myeloma (MM) is the most frequent primary malignancy of the spine. We aimed to investigate the clinical presentation, surgical indications and outcomes, complications, survival, and its influencing factors in surgically treated MM patients with symptomatic involvement of the spi...

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Published in:International journal of spine surgery 2020-10, Vol.14 (5), p.785-794
Main Authors: MILAVEC, HELENA, RAVIKUMAR, NIVETHA, SYN, NICHOLAS L., YENTIA SOEKOJO, CINNIE, CHNG, WEE JOO, KUMAR, NARESH
Format: Article
Language:English
Subjects:
Tumor
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Summary:INTRODUCTIONMultiple myeloma (MM) is the most frequent primary malignancy of the spine. We aimed to investigate the clinical presentation, surgical indications and outcomes, complications, survival, and its influencing factors in surgically treated MM patients with symptomatic involvement of the spine (SIS). METHODSRetrospective analysis of prospectively collected data. Out of 350 MM patients treated at our institution over a period of 12 years (2006-2018), we identified 24 patients who were surgically treated for SIS. We collected data on demographics, clinical presentation, comorbidities, surgical indications, and outcomes and investigated the factors predisposing to postoperative complications and survival. RESULTSThe median follow-up duration was 85 months; median overall survival (OS) was 50 months. Clinical presentation at admission included pain (88%), sensory and/or motor deficit (67%), and bowel/bladder dysfunction (25%). Symptomatic pathological fractures were seen in 33%. Predominant surgical indications were rapid neurological deterioration with or without spinal cord compression (SCC), followed by mechanical instability. The majority of our patients benefited from surgery in terms of pain reduction in the short term as well as in the long term. There were 21% patients with surgical-related complications (
ISSN:2211-4599
2211-4599
DOI:10.14444/7112