Outcomes of Coronavirus Disease 2019 (COVID-19) Related Hospitalization Among People With Human Immunodeficiency Virus (HIV) in the ISARIC World Health Organization (WHO) Clinical Characterization Protocol (UK): A Prospective Observational Study

Evidence is conflicting about how human immunodeficiency virus (HIV) modulates coronavirus disease 2019 (COVID-19). We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data wer...

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Bibliographic Details
Published in:Clinical infectious diseases 2021-10, Vol.73 (7), p.e2095-e2106
Main Authors: Geretti, Anna Maria, Stockdale, Alexander J, Kelly, Sophie H, Cevik, Muge, Collins, Simon, Waters, Laura, Villa, Giovanni, Docherty, Annemarie, Harrison, Ewen M, Turtle, Lance, Openshaw, Peter J M, Baillie, J Kenneth, Sabin, Caroline A, Semple, Malcolm G
Format: Article
Language:English
Subjects:
Adult
COVID-19
HIV
HIV Infections - complications
HIV Infections - epidemiology
Hospitalization
Humans
Middle Aged
Observational Studies as Topic
Online Only
SARS-CoV-2
United Kingdom
World Health Organization
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Summary:Evidence is conflicting about how human immunodeficiency virus (HIV) modulates coronavirus disease 2019 (COVID-19). We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) World Health Organization (WHO) Clinical Characterization Protocol (CCP) study. We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, 10 individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy). Among 47 592 patients, 122 (0.26%) had confirmed HIV infection, and 112/122 (91.8%) had a record of antiretroviral therapy. At presentation, HIV-positive people were younger (median 56 vs 74 years; P 
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1605