Cigarette smoking and lung cancer risk according to histologic type in Japanese men and women

Although cigarette smoking is a well‐known risk factor for lung cancer, histology‐specific risk has not been fully clarified in Japan. This case‐control study evaluated the associations between smoking and lung cancer risk according to sex and histologic type. From among patients aged 30 years and o...

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Bibliographic Details
Published in:Cancer science 2013-11, Vol.104 (11), p.1515-1522
Main Authors: Seki, Takako, Nishino, Yoshikazu, Tanji, Fumiya, Maemondo, Makoto, Takahashi, Satomi, Sato, Ikuro, Kawai, Masaaki, Minami, Yuko
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - epidemiology
Adenocarcinoma - etiology
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Cigarette smoking
Cigarettes
Disease
Female
Females
Health risk assessment
Histology
Humans
Japan - epidemiology
Lung cancer
Lung Neoplasms - epidemiology
Lung Neoplasms - etiology
Lung Neoplasms - pathology
Male
Middle Aged
Odds Ratio
Original
Passive smoking
Registries
Risk factors
Small Cell Lung Carcinoma - epidemiology
Small Cell Lung Carcinoma - etiology
Small Cell Lung Carcinoma - pathology
Smoking
Smoking - adverse effects
Smoking - epidemiology
Studies
Surveys and Questionnaires
Tumors
Variables
Womens health
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Summary:Although cigarette smoking is a well‐known risk factor for lung cancer, histology‐specific risk has not been fully clarified in Japan. This case‐control study evaluated the associations between smoking and lung cancer risk according to sex and histologic type. From among patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009, 1670 lung cancer cases and 5855 controls were selected. History of smoking, quantity and duration of smoking, and passive smoking from spouses were assessed using a self‐administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) for each exposure were estimated by unconditional logistic regression. Ever‐smoking was significantly associated with a higher risk of squamous cell and small cell carcinoma. The OR for these two histologic types combined was larger in women (OR = 24.98, 95% CI: 13.50–46.23) than in men (OR = 9.43, 95% CI: 5.73–15.51). Analysis of the quantity and duration of smoking showed that the OR for each exposure level tended to be larger in women than in men. For adenocarcinoma, clear positive associations with quantity and duration‐related factors were observed among men, and a significant positive association with passive smoking from spouses was found among non‐smoking women (OR = 1.44, 95% CI: 1.06–1.95). These results suggest sex‐ and histologic type‐ differences in the association of smoking with lung cancer risk. Although smoking control should be continued to prevent lung cancers, further studies are required to better clarify differences in smoking‐related lung cancer risk between the sexes and histologic types.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12273