Visualization of sodium dynamics in the kidney by magnetic resonance imaging in a multi-site study

Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results d...

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Bibliographic Details
Published in:	Kidney international 2020-11, Vol.98 (5), p.1174-1178
Main Authors:	Grist, James T., Riemer, Frank, Hansen, Esben S.S., Tougaard, Rasmus S., McLean, Mary A., Kaggie, Joshua, Bøgh, Nikolaj, Graves, Martin J., Gallagher, Ferdia A., Laustsen, Christoffer
Format:	Article
Language:	eng
Subjects:	Animals Basic Research Diuresis Kidney - diagnostic imaging Kidney - metabolism Magnetic Resonance Imaging MRI porcine renal sodium Sodium - metabolism Swine Tissue Distribution volunteer
Online Access:	Get full text
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Summary:	Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney. [Display omitted]
ISSN:	0085-2538 1523-1755