Definition and diagnosis of fracture-related infection

Fracture-related infection (FRI) is common and often diagnosed late.Accurate diagnosis is the beginning of effective treatment.Diagnosis can be difficult, particularly when there are no outward signs of infection.The new FRI definition, together with clear protocols for nuclear imaging, microbiologi...

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Bibliographic Details
Published in:EFORT Open Reviews 2020-10, Vol.5 (10), p.614-619
Main Authors: McNally, Martin, Govaert, Geertje, Dudareva, Maria, Morgenstern, Mario, Metsemakers, Willem-Jan
Format: Article
Language:English
Subjects:
definition
Diagnosis
fracture
fracture-related infection (FRI)
Fractures
histopathology
Infections
Instructional Lecture: General Orthopaedics
medical imaging
microbiology
serum inflammatory markers
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Summary:Fracture-related infection (FRI) is common and often diagnosed late.Accurate diagnosis is the beginning of effective treatment.Diagnosis can be difficult, particularly when there are no outward signs of infection.The new FRI definition, together with clear protocols for nuclear imaging, microbiological culture and histological analysis, should allow much better study design and a clearer understanding of infected fractures.In recent years, there has been a new focus on defining FRI and avoiding non-specific, poorly targeted treatment. Previous studies on FRI have often failed to define infection precisely and so are of limited value. This review highlights the essential principles of making the diagnosis and how clinical signs, serum tests, imaging, microbiology, molecular biology and histology all contribute to the diagnostic pathway. Cite this article: 2020;5:614-619. DOI: 10.1302/2058-5241.5.190072.
ISSN:2058-5241
2396-7544
2058-5241
DOI:10.1302/2058-5241.5.190072