Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysis

The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used...

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Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.18713, Article 18713
Main Authors: Tabibzadeh, Alireza, Tameshkel, Fahimeh Safarnezhad, Moradi, Yousef, Soltani, Saber, Moradi-Lakeh, Maziar, Ashrafi, G Hossein, Motamed, Nima, Zamani, Farhad, Motevalian, Seyed Abbas, Panahi, Mahshid, Esghaei, Maryam, Ajdarkosh, Hossein, Mousavi-Jarrahi, Alireza, Niya, Mohammad Hadi Karbalaie
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Adenomatous polyposis coli
Adenomatous Polyposis Coli Protein - genetics
Class I Phosphatidylinositol 3-Kinases - genetics
Colorectal cancer
Colorectal carcinoma
DNA Mutational Analysis
Gastric cancer
Gastrointestinal Neoplasms - genetics
Gastrointestinal tract
Humans
Liver cancer
MAP kinase
MAP Kinase Signaling System - genetics
Meta-analysis
Mutation
Mutation rates
Pancreatic cancer
Prevalence
Proto-Oncogene Proteins p21(ras) - genetics
Signal Transduction
Systematic review
Wnt protein
Wnt Signaling Pathway - genetics
β-Catenin
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Summary:The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used to calculate the pooled estimate of prevalence via Metaprop command. The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer were 5% (95% CI: 3-8%), 12% (95% CI: 8-18%), 17% (95% CI: 14-20%), and 20% (95% CI: 5-41%), respectively. Also, the mutation rates for Wnt pathway and MAPK pathway were calculated to be 23% (95% CI, 14-33%) and 20% (95% CI, 17-24%), respectively. Moreover, the most popular genes were APC (in Wnt pathway), KRAS (in MAPK pathway) and PIK3CA (in PI3K pathway) in the colorectal cancer, pancreatic cancer, and gastric cancer while they were beta-catenin and CTNNB1 in liver cancer. The most altered pathway was Wnt pathway followed by the MAPK pathway. In addition, pancreatic cancer was found to be higher under the pressure of mutation compared with others based on pooled prevalence analysis. Finally, APC mutations in colorectal cancer, KRAS in gastric cancer, and pancreatic cancer were mostly associated gene alterations.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-73770-1