Skin microbiota in health and disease: From sequencing to biology

Microbiota live in a closely regulated interaction with their environment, and vice versa. The presence and absence of microbial entities is greatly influenced by features of the niche in which they thrive. Characteristic of this phenomenon is that different human skin sites harbor niche‐specific co...

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Bibliographic Details
Published in:Journal of dermatology 2020-10, Vol.47 (10), p.1110-1118
Main Authors: Ederveen, Thomas H. A., Smits, Jos P. H., Boekhorst, Jos, Schalkwijk, Joost, Bogaard, Ellen H., Zeeuwen, Patrick L. J. M.
Format: Article
Language:English
Subjects:
bioinformatics
Biology
Cosmetics
cutaneous diseases
Diet
Humans
Microbiomes
microbiomics
Microbiota
next‐generation sequencing
Niches
Probiotics
Review
Skin
Skin diseases
skin microbiota
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Summary:Microbiota live in a closely regulated interaction with their environment, and vice versa. The presence and absence of microbial entities is greatly influenced by features of the niche in which they thrive. Characteristic of this phenomenon is that different human skin sites harbor niche‐specific communities of microbes. Microbial diversity is considerable, and the current challenge lies in determining which microbes and (corresponding) functionality are of importance to a given ecological niche. Furthermore, as there is increasing evidence of microbial involvement in health and disease, the need arises to fundamentally understand microbiome processes for application in health care, nutrition and personal care products (e.g. diet, cosmetics, probiotics). This review provides a current overview of state‐of‐the‐art sequencing‐based techniques and corresponding data analysis methodology for profiling of complex microbial communities. Furthermore, we also summarize the existing knowledge regarding cutaneous microbiota and their human host for a wide range of skin diseases.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.15536