SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their e...

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Bibliographic Details

Published in:	Nature (London) 2020-10, Vol.586 (7830), p.567-571
Main Authors:	Corbett, Kizzmekia S, Edwards, Darin K, Leist, Sarah R, Abiona, Olubukola M, Boyoglu-Barnum, Seyhan, Gillespie, Rebecca A, Himansu, Sunny, Schäfer, Alexandra, Ziwawo, Cynthia T, DiPiazza, Anthony T, Dinnon, Kenneth H, Elbashir, Sayda M, Shaw, Christine A, Woods, Angela, Fritch, Ethan J, Martinez, David R, Bock, Kevin W, Minai, Mahnaz, Nagata, Bianca M, Hutchinson, Geoffrey B, Wu, Kai, Henry, Carole, Bahl, Kapil, Garcia-Dominguez, Dario, Ma, LingZhi, Renzi, Isabella, Kong, Wing-Pui, Schmidt, Stephen D, Wang, Lingshu, Zhang, Yi, Phung, Emily, Chang, Lauren A, Loomis, Rebecca J, Altaras, Nedim Emil, Narayanan, Elisabeth, Metkar, Mihir, Presnyak, Vlad, Liu, Cuiping, Louder, Mark K, Shi, Wei, Leung, Kwanyee, Yang, Eun Sung, West, Ande, Gully, Kendra L, Stevens, Laura J, Wang, Nianshuang, Wrapp, Daniel, Doria-Rose, Nicole A, Stewart-Jones, Guillaume, Bennett, Hamilton, Alvarado, Gabriela S, Nason, Martha C, Ruckwardt, Tracy J, McLellan, Jason S, Denison, Mark R, Chappell, James D, Moore, Ian N, Morabito, Kaitlyn M, Mascola, John R, Baric, Ralph S, Carfi, Andrea, Graham, Barney S
Format:	Article
Language:	eng
Subjects:	Analysis Animals Antibodies Antibodies, Neutralizing - immunology Betacoronavirus - genetics Betacoronavirus - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Clinical Trials, Phase III as Topic Coronaviridae Coronavirus Infections - genetics Coronavirus Infections - immunology Coronavirus Infections - prevention & control Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Vaccines Disease control Female Immunopathology Lung - immunology Lung - virology Lymphocytes Lymphocytes T Mice Middle East respiratory syndrome mRNA mRNA vaccines Mutation Nose - immunology Nose - virology Pandemics Pandemics - prevention & control Pneumonia, Viral - immunology Pneumonia, Viral - prevention & control Pneumonia, Viral - virology Proteins Respiratory diseases RNA, Messenger - genetics RNA, Viral - genetics SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike protein Th1 Cells - immunology Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - immunology Vaccines Viral diseases Viral Vaccines - chemistry Viral Vaccines - genetics Viral Vaccines - immunology
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