Emerging role of the Hippo pathway in autophagy

Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant b...

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Bibliographic Details
Published in:Cell death & disease 2020-10, Vol.11 (10), p.880-880, Article 880
Main Authors: Wang, Dongying, He, Jiaxing, Huang, Bingyu, Liu, Shanshan, Zhu, Hongming, Xu, Tianmin
Format: Article
Language:English
Subjects:
Animals
Autophagy
Autophagy - physiology
Cell Proliferation
Circulatory system
Drosophila - metabolism
Homeostasis
Humans
Lysosomes
Macromolecules
Mice
Mice, Transgenic
Pathogenesis
Phagocytosis
Protein-Serine-Threonine Kinases - metabolism
Review
Yes-associated protein
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Summary:Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeostasis. The Hippo-YAP pathway has significant biological properties in controlling organ size, tissue homeostasis, and regeneration. Recently, the Hippo-YAP axis has been extensively referred to as the pathophysiological processes regulating autophagy. Understanding the cellular and molecular basis of these processes is crucial for identifying disease pathogenesis and novel therapeutic targets. Here we review recent findings from Drosophila models to organisms. We particularly emphasize the regulation between Hippo core components and autophagy, which is involved in normal cellular regulation and the pathogenesis of human diseases, and its application to disease treatment.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-020-03069-6