Diversity of voltage-gated potassium channels and cyclic nucleotide-binding domain-containing channels in eukaryotes

Voltage-gated potassium channels (K ) and cyclic nucleotide-binding domain-containing cation channels HCN, CNG, and KCNH are the evolutionarily related families of ion channels in animals. Their homologues were found in several lineages of eukaryotes and prokaryotes; however, the actual phylogenetic...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-10, Vol.10 (1), p.17758-17758, Article 17758
Main Authors: Pozdnyakov, Ilya, Safonov, Pavel, Skarlato, Sergei
Format: Article
Language:English
Subjects:
Animals
Cyclic Nucleotide-Gated Cation Channels - metabolism
Databases, Protein
Ether-A-Go-Go Potassium Channels - metabolism
Eukaryota - metabolism
Evolution, Molecular
Humans
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism
Phylogeny
Potassium Channels, Voltage-Gated - metabolism
Protein Conformation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Voltage-gated potassium channels (K ) and cyclic nucleotide-binding domain-containing cation channels HCN, CNG, and KCNH are the evolutionarily related families of ion channels in animals. Their homologues were found in several lineages of eukaryotes and prokaryotes; however, the actual phylogenetic and structural diversity of these ion channels remains unclear. In this work, we present a taxonomically broad investigation of evolutionary relationships and structural diversity of K , HCN, CNG, and KCNH and their homologues in eukaryotes focusing on channels from different protistan groups. We demonstrate that both groups of channels consist of a more significant number of lineages than it was shown before, and these lineages can be grouped in two clusters termed K -like channels and CNBD-channels. Moreover, we, for the first time, report the unusual two-repeat tandem K -like channels and CNBD-channels in several eukaryotic groups, i.e. dinoflagellates, oomycetes, and chlorarachniophytes. Our findings reveal still underappreciated phylogenetic and structural diversity of eukaryotic ion channel lineages.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-74971-4