HIV/SIV DNA vaccine combined with protein in a co-immunization protocol elicits highest humoral responses to envelope in mice and macaques

Highlights • DNA&protein co-immunization induces high antibody responses in mice and macaques. • EM-005 protein adjuvant further augments humoral immunity. • EM-005 enhances the maturation and cytokine production of DCs. • DNA&protein co-immunization provides a promising vaccine regimen for...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (36), p.3747-3755
Main Authors: Li, Jinyao, Valentin, Antonio, Kulkarni, Viraj, Rosati, Margherita, Beach, Rachel Kelly, Alicea, Candido, Hannaman, Drew, Reed, Steven G, Felber, Barbara K, Pavlakis, George N
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants
Adjuvants, Immunologic - pharmacology
AIDS Vaccines - administration & dosage
AIDS Vaccines - immunology
Allergy and Immunology
Animals
Antibody
Applied microbiology
Biological and medical sciences
cell-mediated immunity
Cellular responses
Cross Protection
Dendritic cell maturation
dendritic cells
Dendritic Cells - immunology
Deoxyribonucleic acid
DNA
Electroporation
Fundamental and applied biological sciences. Psychology
HIV Antibodies - blood
HIV Envelope Protein gp120 - immunology
HIV Infections - immunology
HIV Infections - prevention & control
HIV-1
Human immunodeficiency virus
humoral immunity
Humoral responses
immune response
Immune system
Immunity, Cellular
Immunity, Humoral
Immunization
interleukin-6
Interleukin-6 - immunology
Macaca
Membrane Glycoproteins - immunology
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Neutralizing antibody
Plasmids
Proteins
recombinant vaccines
Simian Immunodeficiency Virus
T-lymphocytes
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, DNA - administration & dosage
Vaccines, DNA - immunology
Viral Envelope Proteins - immunology
Virology
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Description
Summary:Highlights • DNA&protein co-immunization induces high antibody responses in mice and macaques. • EM-005 protein adjuvant further augments humoral immunity. • EM-005 enhances the maturation and cytokine production of DCs. • DNA&protein co-immunization provides a promising vaccine regimen for HIV. • DNA&protein co-immunization for general vaccine application.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.04.037