MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3
MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could...
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| Published in: | Cytotechnology (Dordrecht) 2020-10, Vol.72 (5), p.751-761 |
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MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3 |
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Article |
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Tan, Pei-Yi Wen, Liu-Jing Li, Hua-Nan Chai, Shi-Wei |
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Antibodies Apoptosis Biochemistry Biomedicine Biotechnology Breast cancer Cancer therapies Cell migration Cell proliferation Cells Chemistry Chemistry and Materials Science Chinese medicine MicroRNAs Original Original Article Up-regulation |
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Cytotechnology (Dordrecht), 2020-10, Vol.72 (5), p.751-761 |
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MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer. |
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ISSN: 0920-9069 |
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By targeting E2F2, which may make a potential target for the treatment of breast cancer.</description><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cells</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chinese medicine</subject><subject>MicroRNAs</subject><subject>Original</subject><subject>Original Article</subject><subject>Up-regulation</subject><issn>0920-9069</issn><issn>1573-0778</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU-L1TAUxYMoznP0C7gKuHFh9eZf02wEGWZUGBFE1yFNk74MbfpM0oH59qZ2UHQxq9xwf_dwDgehlwTeEgD5LhNoSdsAhQaAk65hj9CBCMkakLJ7jA6g6kpBq87Qs5xvAEBJwp6iM0YVUEnhgKYv4VsjeGcbdsIhHkMfSsbl6PApLVPwLpkSlvgGz2HcR2ziUMlbk7fP4vFxnU3EfXImF2xNtC5h66YJ93e4mDS6EuKIL-kVe46eeDNl9-L-PUc_ri6_X3xqrr9-_Hzx4bqxgrSlGQz3hDjjLVNODkYNlIOxTvaEt9QJ2fuWMcIkZ8S3vZfAayCmhJSUt4Kxc_R-1z2t_ewG62JJZtKnFGaT7vRigv53E8NRj8utloJLxUUVeH0vkJafq8tFzyFvmUx0y5o15ZzQVlRbFX31H3qzrCnWeJoq0tFqTsoHKS5qF0R0G0V3yqYl5-T8H8sE9Fa53ivXtXL9u3K9hWX7Ua5wHF36K_3A1S9kSqtE</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Tan, Pei-Yi</creator><creator>Wen, Liu-Jing</creator><creator>Li, Hua-Nan</creator><creator>Chai, Shi-Wei</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3</title><author>Tan, Pei-Yi ; 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In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32902720</pmid><doi>10.1007/s10616-020-00418-3</doi><oa>free_for_read</oa></addata></record> |