MiR-548c-3p inhibits the proliferation, migration and invasion of human breast cancer cell by targeting E2F3

MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could...

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Bibliographic Details
Published in:	Cytotechnology (Dordrecht) 2020-10, Vol.72 (5), p.751-761
Main Authors:	Tan, Pei-Yi, Wen, Liu-Jing, Li, Hua-Nan, Chai, Shi-Wei
Format:	Article
Language:	eng
Subjects:	Apoptosis Biochemistry Biomedicine Biotechnology Breast cancer Cell migration Cell proliferation Chemistry Chemistry and Materials Science Original Original Article
Online Access:	Get full text
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Summary:	MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer.
ISSN:	0920-9069 1573-0778