Pregnancy-associated changes in cervical noncoding RNA

To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. We enrolled 21 pregnant women with term deliveries (≥37 weeks’ gestation) in a prospective cohort and collected cervical swa...

Full description

Saved in:
Bibliographic Details
Published in:Epigenomics 2020-06, Vol.12 (12), p.1013-1025
Main Authors: Gerson, Kristin D, Haviland, Miriam J, Neo, Dayna, Hecht, Jonathan L, Baccarelli, Andrea A, Brennan, Kasey Jm, Dereix, Alexandra E, Ralston, Steven J, Hacker, Michele R, Burris, Heather H
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
cervix
Cervix Uteri
epigenetics
Female
Gene Expression Profiling
gene ontology
Humans
long noncoding RNA
microRNA
MicroRNAs - genetics
noncoding RNA
Pregnancy
RNA, Long Noncoding - genetics
Short Communication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To identify pregnancy-associated changes in cervical noncoding RNA (ncRNA), including miRNA and long noncoding RNA (lncRNA), and their potential effects on biologic processes. We enrolled 21 pregnant women with term deliveries (≥37 weeks’ gestation) in a prospective cohort and collected cervical swabs before 28 weeks’ gestation. We enrolled 21 nonpregnant controls. We analyzed miRNA, lncRNA and mRNA expression, applying a Bonferroni correction. Five miRNA and three lncRNA were significantly differentially (>twofold change) expressed. Putative miRNA targets are enriched in genes mediating organogenesis, glucocorticoid signaling, cell adhesion and ncRNA machinery. Differential cervical ncRNA expression occurs in the setting of pregnancy. Gene ontology classification reveals biological pathways through which miRNA may play a biologic role in normal pregnancy physiology.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2019-0231