VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN

Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(...

Full description

Saved in:
Bibliographic Details
Published in:Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2020-04, Vol.16 (2), p.136-141
Main Authors: Aktaş, Ş H, Pençe, H H, Özçelik, F, Sayir, N, Sapmaz, T, Kutlu, O, Karabela, Ş N, Elcioglu, H K
Format: Article
Language:English
Subjects:
General Endocrinology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 141
container_issue 2
container_start_page 136
container_title Acta endocrinologica (Bucharest, Romania : 2005)
container_volume 16
creator Aktaş, Ş H
Pençe, H H
Özçelik, F
Sayir, N
Sapmaz, T
Kutlu, O
Karabela, Ş N
Elcioglu, H K
description Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(STZ) induced diabetic rats. Twelve Spraque Dawley albino rats were included in the study. The animals were divided into two groups. The first group was diabetic (D) (n: 6) and 60mg / kg STZ was administered intraperitoneally (i.p.) to these rats. The second group was the non-diabetic control (ND) group (n: 6). All the animals were euthanized by cervical dislocation. Quantification of vaspin, Adiponectin, leptin in serum was performed using the ELISA kit. Adiponectin, vaspin levels of diabetic group were found to be statistically lower than of control group (p
doi_str_mv 10.4183/aeb.2020.136
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7535878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2449256543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c341t-850cf38006dedeba6f09e68f5e70209b281646f05027531c93248fda989bb9043</originalsourceid><addsrcrecordid>eNpVUU1Pg0AQ3RiN1erNs9mjh1L3C9i9mFBAJSFAWlqtlw3QRWvaUqE18d-72NroaV5m3rz5eABcYdRnmNPbTOV9ggjqY2odgTPMGTWQZT0f_2BsIMHtDjhvmneETI4wPgUdShERhPAz8DRxRkkQ9aDjBUkc-W4aRNCJPBj6SQtDf-KHI6hROk18iKEXOAM_DVw4dNI2741d34ODKRylQ90Sv8Rp7AbRBTgps0WjLvexC8b3fuo-GmH8ELhOaBSU4Y3BTVSUlCNkzdRM5ZlVIqEsXprK1ieJnHBsMZ00EbFNigtBCePlLBNc5LlAjHbB3U53vc2Xalao1abOFnJdz5dZ_SWrbC7_V1bzN_lafUotZ3Kba4GbvUBdfWxVs5HLeVOoxSJbqWrbSMKYIKZlMqqpvR21qKumqVV5GIORbL2Q2gvZeiG1F5p-_Xe1A_n3-fQbKBt86g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449256543</pqid></control><display><type>article</type><title>VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN</title><source>Open Access: PubMed Central</source><creator>Aktaş, Ş H ; Pençe, H H ; Özçelik, F ; Sayir, N ; Sapmaz, T ; Kutlu, O ; Karabela, Ş N ; Elcioglu, H K</creator><creatorcontrib>Aktaş, Ş H ; Pençe, H H ; Özçelik, F ; Sayir, N ; Sapmaz, T ; Kutlu, O ; Karabela, Ş N ; Elcioglu, H K</creatorcontrib><description>Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(STZ) induced diabetic rats. Twelve Spraque Dawley albino rats were included in the study. The animals were divided into two groups. The first group was diabetic (D) (n: 6) and 60mg / kg STZ was administered intraperitoneally (i.p.) to these rats. The second group was the non-diabetic control (ND) group (n: 6). All the animals were euthanized by cervical dislocation. Quantification of vaspin, Adiponectin, leptin in serum was performed using the ELISA kit. Adiponectin, vaspin levels of diabetic group were found to be statistically lower than of control group (p&lt;0.05). Leptin levels were significantly higher in the diabetic group (P&lt;0.05). There is a need for new researches that can explain the relationship between Vaspin, Leptin and Adiponectin and Type 1 diabetes. New studies in this area will open new horizons for the identification of new biomarkers in the diagnosis and treatment of Type 1 diabetes.</description><identifier>ISSN: 1841-0987</identifier><identifier>EISSN: 1843-066X</identifier><identifier>DOI: 10.4183/aeb.2020.136</identifier><identifier>PMID: 33029228</identifier><language>eng</language><publisher>Romania: Acta Endocrinologica Foundation</publisher><subject>General Endocrinology</subject><ispartof>Acta endocrinologica (Bucharest, Romania : 2005), 2020-04, Vol.16 (2), p.136-141</ispartof><rights>by Acta Endocrinologica Foundation.</rights><rights>by Acta Endocrinologica Foundation 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535878/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535878/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33029228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aktaş, Ş H</creatorcontrib><creatorcontrib>Pençe, H H</creatorcontrib><creatorcontrib>Özçelik, F</creatorcontrib><creatorcontrib>Sayir, N</creatorcontrib><creatorcontrib>Sapmaz, T</creatorcontrib><creatorcontrib>Kutlu, O</creatorcontrib><creatorcontrib>Karabela, Ş N</creatorcontrib><creatorcontrib>Elcioglu, H K</creatorcontrib><title>VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN</title><title>Acta endocrinologica (Bucharest, Romania : 2005)</title><addtitle>Acta Endocrinol (Buchar)</addtitle><description>Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(STZ) induced diabetic rats. Twelve Spraque Dawley albino rats were included in the study. The animals were divided into two groups. The first group was diabetic (D) (n: 6) and 60mg / kg STZ was administered intraperitoneally (i.p.) to these rats. The second group was the non-diabetic control (ND) group (n: 6). All the animals were euthanized by cervical dislocation. Quantification of vaspin, Adiponectin, leptin in serum was performed using the ELISA kit. Adiponectin, vaspin levels of diabetic group were found to be statistically lower than of control group (p&lt;0.05). Leptin levels were significantly higher in the diabetic group (P&lt;0.05). There is a need for new researches that can explain the relationship between Vaspin, Leptin and Adiponectin and Type 1 diabetes. New studies in this area will open new horizons for the identification of new biomarkers in the diagnosis and treatment of Type 1 diabetes.</description><subject>General Endocrinology</subject><issn>1841-0987</issn><issn>1843-066X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVUU1Pg0AQ3RiN1erNs9mjh1L3C9i9mFBAJSFAWlqtlw3QRWvaUqE18d-72NroaV5m3rz5eABcYdRnmNPbTOV9ggjqY2odgTPMGTWQZT0f_2BsIMHtDjhvmneETI4wPgUdShERhPAz8DRxRkkQ9aDjBUkc-W4aRNCJPBj6SQtDf-KHI6hROk18iKEXOAM_DVw4dNI2741d34ODKRylQ90Sv8Rp7AbRBTgps0WjLvexC8b3fuo-GmH8ELhOaBSU4Y3BTVSUlCNkzdRM5ZlVIqEsXprK1ieJnHBsMZ00EbFNigtBCePlLBNc5LlAjHbB3U53vc2Xalao1abOFnJdz5dZ_SWrbC7_V1bzN_lafUotZ3Kba4GbvUBdfWxVs5HLeVOoxSJbqWrbSMKYIKZlMqqpvR21qKumqVV5GIORbL2Q2gvZeiG1F5p-_Xe1A_n3-fQbKBt86g</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Aktaş, Ş H</creator><creator>Pençe, H H</creator><creator>Özçelik, F</creator><creator>Sayir, N</creator><creator>Sapmaz, T</creator><creator>Kutlu, O</creator><creator>Karabela, Ş N</creator><creator>Elcioglu, H K</creator><general>Acta Endocrinologica Foundation</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200401</creationdate><title>VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN</title><author>Aktaş, Ş H ; Pençe, H H ; Özçelik, F ; Sayir, N ; Sapmaz, T ; Kutlu, O ; Karabela, Ş N ; Elcioglu, H K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-850cf38006dedeba6f09e68f5e70209b281646f05027531c93248fda989bb9043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>General Endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aktaş, Ş H</creatorcontrib><creatorcontrib>Pençe, H H</creatorcontrib><creatorcontrib>Özçelik, F</creatorcontrib><creatorcontrib>Sayir, N</creatorcontrib><creatorcontrib>Sapmaz, T</creatorcontrib><creatorcontrib>Kutlu, O</creatorcontrib><creatorcontrib>Karabela, Ş N</creatorcontrib><creatorcontrib>Elcioglu, H K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta endocrinologica (Bucharest, Romania : 2005)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aktaş, Ş H</au><au>Pençe, H H</au><au>Özçelik, F</au><au>Sayir, N</au><au>Sapmaz, T</au><au>Kutlu, O</au><au>Karabela, Ş N</au><au>Elcioglu, H K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN</atitle><jtitle>Acta endocrinologica (Bucharest, Romania : 2005)</jtitle><addtitle>Acta Endocrinol (Buchar)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>16</volume><issue>2</issue><spage>136</spage><epage>141</epage><pages>136-141</pages><issn>1841-0987</issn><eissn>1843-066X</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(STZ) induced diabetic rats. Twelve Spraque Dawley albino rats were included in the study. The animals were divided into two groups. The first group was diabetic (D) (n: 6) and 60mg / kg STZ was administered intraperitoneally (i.p.) to these rats. The second group was the non-diabetic control (ND) group (n: 6). All the animals were euthanized by cervical dislocation. Quantification of vaspin, Adiponectin, leptin in serum was performed using the ELISA kit. Adiponectin, vaspin levels of diabetic group were found to be statistically lower than of control group (p&lt;0.05). Leptin levels were significantly higher in the diabetic group (P&lt;0.05). There is a need for new researches that can explain the relationship between Vaspin, Leptin and Adiponectin and Type 1 diabetes. New studies in this area will open new horizons for the identification of new biomarkers in the diagnosis and treatment of Type 1 diabetes.</abstract><cop>Romania</cop><pub>Acta Endocrinologica Foundation</pub><pmid>33029228</pmid><doi>10.4183/aeb.2020.136</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1841-0987
ispartof Acta endocrinologica (Bucharest, Romania : 2005), 2020-04, Vol.16 (2), p.136-141
issn 1841-0987
1843-066X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7535878
source Open Access: PubMed Central
subjects General Endocrinology
title VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T01%3A53%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=VASPIN,%20ADIPONECTIN%20AND%20LEPTIN%20LEVELS%20IN%20TYPE%201%20DIABETIC%20RATS%20INDUCED%20BY%20STREPTOZOTOCIN&rft.jtitle=Acta%20endocrinologica%20(Bucharest,%20Romania%20:%202005)&rft.au=Akta%C5%9F,%20%C5%9E%20H&rft.date=2020-04-01&rft.volume=16&rft.issue=2&rft.spage=136&rft.epage=141&rft.pages=136-141&rft.issn=1841-0987&rft.eissn=1843-066X&rft_id=info:doi/10.4183/aeb.2020.136&rft_dat=%3Cproquest_pubme%3E2449256543%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c341t-850cf38006dedeba6f09e68f5e70209b281646f05027531c93248fda989bb9043%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2449256543&rft_id=info:pmid/33029228&rfr_iscdi=true