VASPIN, ADIPONECTIN AND LEPTIN LEVELS IN TYPE 1 DIABETIC RATS INDUCED BY STREPTOZOTOCIN

Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(...

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Bibliographic Details
Published in:Acta endocrinologica (Bucharest, Romania : 2005) Romania : 2005), 2020-04, Vol.16 (2), p.136-141
Main Authors: Aktaş, Ş H, Pençe, H H, Özçelik, F, Sayir, N, Sapmaz, T, Kutlu, O, Karabela, Ş N, Elcioglu, H K
Format: Article
Language:English
Subjects:
General Endocrinology
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Summary:Adiponectin, vaspin and leptin are only a few of these numerous adipocytokines. Little is known about the behavior of adipocytokines and how adipose tissue metabolism is affected in this Type 1 DM model. In this study we investigated the serum levels of adiponectin, leptin, vaspin in streptozotocin(STZ) induced diabetic rats. Twelve Spraque Dawley albino rats were included in the study. The animals were divided into two groups. The first group was diabetic (D) (n: 6) and 60mg / kg STZ was administered intraperitoneally (i.p.) to these rats. The second group was the non-diabetic control (ND) group (n: 6). All the animals were euthanized by cervical dislocation. Quantification of vaspin, Adiponectin, leptin in serum was performed using the ELISA kit. Adiponectin, vaspin levels of diabetic group were found to be statistically lower than of control group (p
ISSN:1841-0987
1843-066X
DOI:10.4183/aeb.2020.136