Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort

Ocular melanomas are uncommon cancers in Southeast Asia unlike in the West. We conducted a retrospective review of patients (n = 44) with histologically-proven ocular melanoma within a multi-ethnic Asian cohort from Singapore. Clinicopathological features and relapse patterns were examined, and surv...

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Published in:Scientific reports 2020-10, Vol.10 (1), p.16367-16367, Article 16367
Main Authors: Tan, Laura Ling Ying, Hong, Jiancheng, Goh, Wei Lin, Chang, Esther Wei Yin, Yang, Valerie Shiwen, Poon, Eileen, Somasundaram, Nagavalli, Farid, Mohamad, Chan, Anita Sook Yee, Chan, Jason Yongsheng
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Disease-Free Survival
Ethnic Groups
Eye Neoplasms - diagnosis
Eye Neoplasms - mortality
Eye Neoplasms - pathology
Female
Humans
Male
Melanoma
Melanoma - diagnosis
Melanoma - mortality
Melanoma - pathology
Metastases
Middle Aged
Multivariate analysis
Neoplasm Staging
Prognosis
Retrospective Studies
Singapore
Survival
Survival Analysis
Survival Rate
Young Adult
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Summary:Ocular melanomas are uncommon cancers in Southeast Asia unlike in the West. We conducted a retrospective review of patients (n = 44) with histologically-proven ocular melanoma within a multi-ethnic Asian cohort from Singapore. Clinicopathological features and relapse patterns were examined, and survival outcomes of interest included recurrence-free survival (RFS) and overall survival (OS). Survival analysis was performed using the Kaplan-Meier method and multivariable Cox proportional regression. The study cohort included 18 male and 26 female patients, with a median age of 52 years (range 8-78). Median follow-up was 154 months. For uveal melanomas (n = 29), the 5-year RFS and OS was 56.8% and 76.6%, respectively; whilst for conjunctival melanomas (n = 15), the 5-year RFS and OS was 30.1% and 68.8%, respectively. Fifteen patients (38.5%) eventually developed metastasis, following which the median survival was only 17 months. Multivariate analysis demonstrated that higher T stage was a significant independent predictor for both OS (HR 8.69, 95% CI 1.03 to 73.09, p = 0.047) and RFS (HR 11.62, 95% CI 2.45 to 55.00, p = 0.002). Smoking history was independently predictive of better RFS (HR 0.08, 95% CI 0.01 to 0.78, p = 0.030). In conclusion, our study demonstrates the poor ocular melanoma outcomes in Southeast Asians, highlighting the necessity for urgent research in this area of unmet clinical need.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-73534-x