Significance of Lymphovascular Space Invasion by the Sarcomatous Component in Uterine Carcinosarcoma

Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospecti...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2018-09, Vol.25 (9), p.2756-2766
Main Authors: Matsuo, Koji, Takazawa, Yutaka, Ross, Malcolm S., Elishaev, Esther, Yunokawa, Mayu, Sheridan, Todd B., Bush, Stephen H., Klobocista, Merieme M., Blake, Erin A., Takano, Tadao, Baba, Tsukasa, Satoh, Shinya, Shida, Masako, Ikeda, Yuji, Adachi, Sosuke, Yokoyama, Takuhei, Takekuma, Munetaka, Yanai, Shiori, Takeuchi, Satoshi, Nishimura, Masato, Iwasaki, Keita, Johnson, Marian S., Yoshida, Masayuki, Hakam, Ardeshir, Machida, Hiroko, Mhawech-Fauceglia, Paulette, Ueda, Yutaka, Yoshino, Kiyoshi, Kajiwara, Hiroshi, Hasegawa, Kosei, Yasuda, Masanori, Miyake, Takahito M., Moriya, Takuya, Yuba, Yoshiaki, Morgan, Terry, Fukagawa, Tomoyuki, Pejovic, Tanja, Nagano, Tadayoshi, Sasaki, Takeshi, Richmond, Abby M., Post, Miriam D., Shahzad, Mian M. K., Im, Dwight D., Yoshida, Hiroshi, Enomoto, Takayuki, Omatsu, Kohei, Ueland, Frederick R., Kelley, Joseph L., Karabakhtsian, Rouzan G., Roman, Lynda D.
Format: Article
Language:English
Subjects:
Blood Vessels - pathology
Carcinosarcoma - pathology
Carcinosarcoma - therapy
Chemotherapy, Adjuvant
Disease Progression
Dominance
Female
Gynecologic Oncology
Humans
Hysterectomy
Lymphatic Metastasis
Lymphatic Vessels - pathology
Medicine
Medicine & Public Health
Middle Aged
Multivariate analysis
Neoplasm Invasiveness
Oncology
Progression-Free Survival
Radiation therapy
Radiotherapy, Adjuvant
Retrospective Studies
Sarcoma
Surgery
Surgical Oncology
Survival
Survival Rate
Tumors
Uterine Neoplasms - pathology
Uterine Neoplasms - therapy
Uterus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective The aim of this study was to examine the significance of lymphovascular space invasion (LVSI) with a sarcomatous component on the tumor characteristics and clinical outcomes of women with uterine carcinosarcoma (UCS). Methods This was a secondary analysis of a prior multicenter retrospective study that examined women with stage I–IV UCS who underwent primary hysterectomy. Archived histopathology slides were reviewed and LVSI was scored as follows: LVSI with a carcinomatous component alone (LVSI-carcinoma; n  = 375, 76.8%) or LVSI containing a sarcomatous component with or without a carcinomatous component (LVSI-sarcoma; n  = 113, 23.2%). Qualitative metrics of LVSI were correlated to clinicopathological factors and survival outcome. Results Tumors in the LVSI-sarcoma group were more likely to have sarcoma dominance (82.1 vs. 26.4%) heterologous sarcomatous component (51.3 vs. 37.9%), low-grade carcinoma (42.5 vs. 22.4%), and large tumor size (81.0 vs. 70.2%) in the primary tumor site compared with tumors in the LVSI-carcinoma group (all p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-018-6547-x