Determinants of suboptimal CD4+ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV‐1 infection

Introduction Up to 30% of individuals treated with antiretroviral therapy (ART) during chronic HIV fail to recover CD4 counts to >500 cells/mm3 despite plasma viral suppression. We investigated the frequency and associations of suboptimal CD4 recovery after ART started during acute HIV infection...

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Bibliographic Details
Published in:Journal of the International AIDS Society 2020-09, Vol.23 (9), p.e25585-n/a
Main Authors: Handoko, Ryan, Colby, Donn J, Kroon, Eugène, Sacdalan, Carlo, Souza, Mark, Pinyakorn, Suteeraporn, Prueksakaew, Peeriya, Munkong, Chutharat, Ubolyam, Sasiwimol, Akapirat, Siriwat, Chiarella, Jennifer, Krebs, Shelly, Sereti, Irini, Valcour, Victor, Paul, Robert, Michael, Nelson L., Phanuphak, Nittaya, Ananworanich, Jintanat, Spudich, Serena
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
AIDS/HIV
Anti-HIV Agents - therapeutic use
Antigens
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Antiviral agents
ARV
Asia
CD4 Lymphocyte Count
CD4 lymphocytes
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cohort Studies
Drug therapy
Health aspects
Hepatitis
HIV
HIV care continuum
HIV infection
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - immunology
Human immunodeficiency virus
Humans
immunology
Infections
Laboratories
LMIC
Lymphocytes
Male
Measurement
men who have sex with men
Middle Aged
Patient outcomes
Prospective Studies
Regression analysis
Tumor necrosis factor-TNF
Young Adult
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Summary:Introduction Up to 30% of individuals treated with antiretroviral therapy (ART) during chronic HIV fail to recover CD4 counts to >500 cells/mm3 despite plasma viral suppression. We investigated the frequency and associations of suboptimal CD4 recovery after ART started during acute HIV infection (AHI). Methods Participants who started ART in Fiebig I to V AHI with ≥48 weeks of continuous documented HIV‐RNA 
ISSN:1758-2652
1758-2652
DOI:10.1002/jia2.25585