Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination

The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination an...

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Bibliographic Details
Published in:Scientific reports 2020-09, Vol.10 (1), p.15392, Article 15392
Main Authors: Tan, Susanna K, Granados, Andrea C, Bouquet, Jerome, Hoy-Schulz, Yana Emmy, Green, Lauri, Federman, Scot, Stryke, Doug, Haggerty, Thomas D, Ley, Catherine, Yeh, Ming-Te, Jannat, Kaniz, Maldonado, Yvonne A, Andino, Raul, Parsonnet, Julie, Chiu, Charles Y
Format: Article
Language:English
Subjects:
Antibodies, Neutralizing - immunology
Antibodies, Viral - blood
Bangladesh - epidemiology
Feces - virology
Female
Humans
Immunization Schedule
Infant
Male
Metagenome - genetics
Metagenomics - methods
Poliomyelitis - virology
Poliovirus - genetics
Poliovirus - immunology
Poliovirus Vaccine, Inactivated - immunology
Poliovirus Vaccine, Oral - immunology
Vaccination
Virome - genetics
Virus Shedding - genetics
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Summary:The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antibodies. The abundance (p = 0.006) and richness (p = 0.013) of the eukaryotic virome increased with age and were higher than seen in age-matched US infants (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-71791-4