Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study

Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression grou...

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Bibliographic Details
Published in:Scientific reports 2020-09, Vol.10 (1), p.15265-15265, Article 15265
Main Authors: Wang, Sheng-Min, Park, Sung-Soo, Park, Si-Hyun, Kim, Nak-Young, Kang, Dong Woo, Na, Hae-Ran, Lee, Jong Wook, Han, Seunghoon, Lim, Hyun Kook
Format: Article
Language:English
Subjects:
Anxiety Disorders - psychology
Depression - psychology
Female
Hematopoietic Stem Cell Transplantation - mortality
Hematopoietic Stem Cell Transplantation - psychology
Humans
Male
Middle Aged
Patients - psychology
Republic of Korea
Retrospective Studies
Survival Rate
Transplantation, Homologous - mortality
Transplantation, Homologous - psychology
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Summary:Studies investigating association of depression with overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) yielded conflicting results. A nationwide cohort study, which included all adult patients [n = 7,170; depression group, 13.3% (N = 956); non-depression group, 86.7% (N = 6,214)] who received allo-HSCT from 2002 to 2018 in South Korea, analyzed risk of pre-transplant depression in OS of allo-HSCT. Subjects were followed from the day they received allo-HSCT, to occurrence of death, or last follow-up day (December 31, 2018). Median age at allo-HSCT for depression and non-depression groups were 50 and 45 (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-71208-2