Comparison of prostate verification with implanted gold markers in tissue surrounding the prostate and pelvic bony anatomy for external beam radiation therapy following low-dose-rate brachytherapy: a prospective clinical trial

Abstract We aimed to investigate whether gold marker implantation in the tissue surrounding the prostate could accurately monitor setup errors during external beam radiation therapy (EBRT) following low-dose-rate (LDR) brachytherapy. Thirty-eight patients had confirmed intermediate- or high-risk pro...

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Bibliographic Details
Published in:Journal of radiation research 2020-09, Vol.61 (5), p.784-790
Main Authors: Kaneda, Tomoya, Ohashi, Toshio, Hanada, Takashi, Takenaka, Koji, Nishimura, Shuichi, Sakayori, Masanori, Sutani, Shinya, Momma, Tetsuo, Shigematsu, Naoyuki
Format: Article
Language:English
Subjects:
Clinical trials
Comparative analysis
CT imaging
Health aspects
Prostate cancer
Radioisotope brachytherapy
Regular Paper
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Summary:Abstract We aimed to investigate whether gold marker implantation in the tissue surrounding the prostate could accurately monitor setup errors during external beam radiation therapy (EBRT) following low-dose-rate (LDR) brachytherapy. Thirty-eight patients had confirmed intermediate- or high-risk prostate cancer and received EBRT following LDR brachytherapy. In >175 computed tomography imaging sessions, the average values of the weekly setup error during EBRT to the prostate centroid at the time of gold marker matching in the surrounding tissue of the prostate and pelvic bone matching were measured and then compared using the Wilcoxon signed-rank test. Gold marker matching in the surrounding tissue of the prostate estimated setup errors better than those estimated by bone matching (3D displacement = 2.7 ± 2.0 vs 3.8 ± 2.6 mm, P 
ISSN:0449-3060
1349-9157
DOI:10.1093/jrr/rraa063