Synthesis and characterization of magnetic nanoparticles coated with polystyrene sulfonic acid for biomedical applications

The development of novel magnetic nanoparticles (MNPs) with satisfactory biocompatibility for biomedical applications has been the subject of extensive exploration over the past two decades. In this work, we synthesized superparamagnetic iron oxide MNPs coated with polystyrene sulfonic acid (PSS-MNP...

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Bibliographic Details
Published in:Science and technology of advanced materials 2020-01, Vol.21 (1), p.471-481
Main Authors: Chen, Bo-Wei, He, Yun-Chi, Sung, Shian-Ying, Le, Trang Thi Huynh, Hsieh, Chia-Ling, Chen, Jiann-Yeu, Wei, Zung-Hang, Yao, Da-Jeng
Format: Article
Language:English
Subjects:
301 Chemical syntheses / processing
503 TEM
504 X-ray / Neutron diffraction and scattering
505 Optical / Molecular spectroscopy
Bio-Inspired and Biomedical Materials
Biocompatibility
biomedical applications
Biomedical materials
Cancer
Cytotoxicity
Diameters
Fibroblasts
Fourier transforms
Infrared analysis
Infrared spectra
Iron oxides
Magnetic nanoparticle
Magnetic saturation
Magnetometers
Nanoparticles
Photon correlation spectroscopy
Polystyrene resins
polystyrene sulfonic acid (PSS)
SEM
203 Magnetics / Spintronics / Superconductors
STEM
Sulfonic acid
Sulfur trioxide
superparamagnetic iron oxide (SPIO)
Thermogravimetric analysis
Toxicity
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Summary:The development of novel magnetic nanoparticles (MNPs) with satisfactory biocompatibility for biomedical applications has been the subject of extensive exploration over the past two decades. In this work, we synthesized superparamagnetic iron oxide MNPs coated with polystyrene sulfonic acid (PSS-MNPs) and with a conventional co-precipitation method. The core size and hydrodynamic diameter of the PSS-MNPs were determined as 8-18 nm and 50-200 nm with a transmission electron microscopy and dynamic light scattering, respectively. The saturation magnetization of the particles was measured as 60 emu g −1 with a superconducting quantum-interference-device magnetometer. The PSS content in the PSS-MNPs was 17% of the entire PSS-MNPs according to thermogravimetric analysis. Fourier-transform infrared spectra were recorded to detect the presence of SO 3 − groups, which confirmed a successful PSS coating. The structural properties of the PSS-MNPs, including the crystalline lattice, composition and phases, were characterized with an X-ray powder diffractometer and 3D nanometer-scale Raman microspectrometer. MTT assay and Prussian-blue staining showed that, although PSS-MNPs caused no cytotoxicity in both NIH-3T3 mouse fibroblasts and SK-HEP1 human liver-cancer cells up to 1000 μg mL −1 , SK-HEP1 cells exhibited significantly greater uptake of PSS-MNPs than NIH-3T3 cells. The low cytotoxicity and high biocompatibility of PSS-MNPs in human cancer cells demonstrated in the present work might have prospective applications for drug delivery.
ISSN:1468-6996
1878-5514
DOI:10.1080/14686996.2020.1790032