Mapping cardiopulmonary dynamics within the microvasculature of the lungs using dissolved 129Xe MRI

Magnetic resonance (MR) imaging and spectroscopy using dissolved hyperpolarized (HP) 129Xe have expanded the ability to probe lung function regionally and noninvasively. In particular, HP 129Xe imaging has been used to quantify impaired gas uptake by the pulmonary tissues. Whole-lung spectroscopy ha...

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Bibliographic Details
Published in:Journal of applied physiology (1985) 2020-08, Vol.129 (2), p.218-229
Main Authors: Niedbalski, Peter J, Bier, Elianna A, Wang, Ziyi, Willmering, Matthew M, Driehuys, Bastiaan, Cleveland, Zackary I
Format: Article
Language:English
Subjects:
Amplitudes
Blood volume
Capillaries
Dynamics
Erythrocytes
Fibrosis
Heterogeneity
Hypertension
Image processing
Image reconstruction
Innovative Methodology
Lung diseases
Lungs
Magnetic resonance imaging
Mapping
Medical imaging
Microvasculature
Oscillations
Pulmonary functions
Regional analysis
Respiratory function
Spectroscopy
Spectrum analysis
Xenon 129
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Summary:Magnetic resonance (MR) imaging and spectroscopy using dissolved hyperpolarized (HP) 129Xe have expanded the ability to probe lung function regionally and noninvasively. In particular, HP 129Xe imaging has been used to quantify impaired gas uptake by the pulmonary tissues. Whole-lung spectroscopy has also been used to assess global cardiogenic oscillations in the MR signal intensity originating from 129Xe dissolved in the red blood cells of pulmonary capillaries. Herein, we show that the magnitude of these cardiogenic dynamics can be mapped three dimensionally using radial MRI, because dissolved 129Xe dynamics are encoded directly in the raw imaging data. Specifically, 1-point Dixon imaging is combined with postacquisition keyhole image reconstruction to assess regional blood volume fluctuations within the pulmonary microvasculature throughout the cardiac cycle. This "oscillation mapping" was applied in healthy subjects (mean amplitude 9% of total RBC signal) and patients with pulmonary arterial hypertension (PAH; mean 4%) and idiopathic pulmonary fibrosis (IPF; mean 14%). Whole-lung mean values from these oscillation maps correlated strongly with spectroscopy and clinical pulmonary function testing, but exhibited significant regional heterogeneity, including gravitationally dependent gradients in healthy subjects. Moreover, regional oscillations were found to be sensitive to disease state. Greater percentages of the lungs exhibit low-amplitude oscillations in PAH patients, and longitudinal imaging shows high-amplitude oscillations increase significantly over time (4–14 mo, P = 0.02) in IPF patients. This technique enables regional dynamics within the pulmonary capillary bed to be measured, and in doing so, provides insight into the origin and progression of pathophysiology within the lung microvasculature.
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00186.2020