Comprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity

Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-plays a critical role in ocular surface physiology. Abnormalities in the chemical composition of meibum were linked to widespread ocular pathologies-dry eye syndrome (DES) and MG dysfunction (MGD). Im...

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Bibliographic Details
Published in:Scientific reports 2020-09, Vol.10 (1), p.14510-14510, Article 14510
Main Authors: Butovich, Igor A, Suzuki, Tomo, Wojtowicz, Jadwiga, Bhat, Nita, Yuksel, Seher
Format: Article
Language:English
Subjects:
Adenosine
Adenosine kinase
Asian People
ATP synthase
Biosynthesis
Cholesterol Esters - metabolism
Electron transport
Eye Diseases - metabolism
Eyelid Diseases - metabolism
Glycolysis
Humans
Lipid Metabolism - physiology
Lipidomics - methods
Mass Spectrometry
Meibomian Glands - metabolism
Metabolism
Metabolites
Metabolomics - methods
Oxidative metabolism
Risk Factors
Secondary metabolites
Tricarboxylic acid cycle
Triglycerides - metabolism
White People
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Summary:Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-plays a critical role in ocular surface physiology. Abnormalities in the chemical composition of meibum were linked to widespread ocular pathologies-dry eye syndrome (DES) and MG dysfunction (MGD). Importantly, in epidemiologic studies the Asian population was shown to be prone to these pathologies more than the Caucasian one, which was tied to differences in their meibomian lipids. However, biochemical data to support these observations and conclusions are limited. To determine if non-DES/non-MGD Asian meibum was significantly different from that of Caucasians, individual samples of meibum collected from ethnic Asian population living in Japan were compared with those of Caucasians living in the USA. These experiments revealed that composition of major lipid classes, such as wax esters (WE), cholesteryl esters (CE), triacylglycerols, (O)-acylated ω-hydroxy fatty acids (OAHFA), cholesteryl sulfate, cholesteryl esters of OAHFA, and diacylated α,ω-dihydroxy fatty alcohols remained invariable in both races, barring a minor (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-71259-5