Chronic complications in patients with newly diagnosed type 2 diabetes: prevalence and related metabolic and clinical features: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 9

IntroductionWe explored the presence of chronic complications in subjects with newly diagnosed type 2 diabetes referred to the Verona Diabetes Clinic. Metabolic (insulin secretion and sensitivity) and clinical features associated with complications were also investigated.Research design and methodsT...

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Published in:BMJ open diabetes research & care 2020-08, Vol.8 (1), p.e001549
Main Authors: Bonora, Enzo, Trombetta, Maddalena, Dauriz, Marco, Travia, Daniela, Cacciatori, Vittorio, Brangani, Corinna, Negri, Carlo, Perrone, Fabrizia, Pichiri, Isabella, Stoico, Vincenzo, Zoppini, Giacomo, Rinaldi, Elisabetta, Da Prato, Giuliana, Boselli, Maria Linda, Santi, Lorenza, Moschetta, Federica, Zardini, Monica, Bonadonna, Riccardo C
Format: Article
Language:English
Subjects:
Antihypertensives
Blood pressure
Body mass index
Cardiovascular disease
Cholesterol
Diabetes
Diabetic retinopathy
Drugs
Fasting
Glucose
Hemoglobin
Hyperglycemia
Hypertension
Insulin resistance
Laboratories
Low density lipoprotein
Medical diagnosis
Metabolism
Pathophysiology/Complications
Plasma
Ultrasonic imaging
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Summary:IntroductionWe explored the presence of chronic complications in subjects with newly diagnosed type 2 diabetes referred to the Verona Diabetes Clinic. Metabolic (insulin secretion and sensitivity) and clinical features associated with complications were also investigated.Research design and methodsThe comprehensive assessment of microvascular and macrovascular complications included detailed medical history, resting ECG, ultrasonography of carotid and lower limb arteries, quantitative neurological evaluation, cardiovascular autonomic tests, ophthalmoscopy, kidney function tests. Insulin sensitivity and beta-cell function were assessed by state-of-the-art techniques (insulin clamp and mathematical modeling of glucose/C-peptide curves during oral glucose tolerance test).ResultsWe examined 806 patients (median age years, two-thirds males), of whom prior clinical cardiovascular disease (CVD) was revealed in 11.2% and preclinical CVD in 7.7%. Somatic neuropathy was found in 21.2% and cardiovascular autonomic neuropathy in 18.6%. Retinopathy was observed in 4.9% (background 4.2%, proliferative 0.7%). Chronic kidney disease (estimated glomerular filtration rate
ISSN:2052-4897
2052-4897
DOI:10.1136/bmjdrc-2020-001549