Possible Modifying Effect of Hemoglobin A1c on Genetic Susceptibility to Severe Diabetic Retinopathy in Patients With Type 2 Diabetes

Glycemic control has been recognized as an important modifiable risk factor for diabetic retinopathy (DR). Whether hemoglobin A1c (HbA1c), as an indicator of glycemic control, could modify the genetic susceptibility to severe DR remains to be investigated. This study aimed to investigate whether HbA...

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Bibliographic Details
Published in:Investigative ophthalmology & visual science 2020-08, Vol.61 (10), p.7-7
Main Authors: Ng, Kelvin K K, Cheung, Chloe Y Y, Lee, Chi-Ho, Fong, Carol H Y, Kwok, Kelvin H M, Li, Kenneth K W, Gangwani, Rita A, Wong, Ian Y H, Woo, Yu-Cho, Chow, Wing-Sun, Yuen, Michele M A, Wong, Rachel L C, Xu, Aimin, Wong, David S H, Sham, Pak-Chung, Lam, Karen S L
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Blood Glucose - metabolism
Case-Control Studies
China - epidemiology
Collagen Type V - genetics
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - genetics
Diabetic Retinopathy - genetics
Female
Genetic Predisposition to Disease - genetics
Genetics
Genome-Wide Association Study
Glycated Hemoglobin A - genetics
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
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Summary:Glycemic control has been recognized as an important modifiable risk factor for diabetic retinopathy (DR). Whether hemoglobin A1c (HbA1c), as an indicator of glycemic control, could modify the genetic susceptibility to severe DR remains to be investigated. This study aimed to investigate whether HbA1c could modulate the genetic susceptibility to severe DR in Chinese patients with type 2 diabetes. A total of 3,093 Chinese individuals with type 2 diabetes were included in the cross-sectional case-control study: 1,051 with sight-threatening DR (STDR) and 2,042 without STDR. Sixty-nine top-ranked single nucleotide polymorphisms (SNPs) identified from previous genome-wide association studies were examined for their associations with STDR and proliferative DR as a subgroup analysis. SNPs showing suggestive associations with DR were examined in the stratified analysis by dichotomized HbA1c (
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.61.10.7