18F-choline PET/CT and PET/MRI in primary and recurrent hyperparathyroidism: a systematic review of the literature

The aims of the present systematic review were to: (1) assess the role of 18 F-fluorocholine (FCH) positron emission tomography (PET) with computed tomography (CT) and PET with magnetic resonance imaging (MRI) in patients with biochemically known hyperparathyroidism; (2) compare the diagnostic perfo...

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Bibliographic Details
Published in:Annals of nuclear medicine 2020-09, Vol.34 (9), p.601-619
Main Authors: Evangelista, Laura, Ravelli, Ilaria, Magnani, Fabio, Iacobone, Maurizio, Giraudo, Chiara, Camozzi, Valentina, Spimpolo, Alessandro, Cecchin, Diego
Format: Article
Language:English
Subjects:
Choline
Computed tomography
Diagnostic systems
Emission analysis
Fluorine isotopes
Hyperparathyroidism
Imaging
Lesions
Literature reviews
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Morphology
Nuclear Medicine
Parathyroid
Photon emission
Positron emission
Positron emission tomography
Radiology
Review
Review Article
Single photon emission computed tomography
Systematic review
Tomography
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Summary:The aims of the present systematic review were to: (1) assess the role of 18 F-fluorocholine (FCH) positron emission tomography (PET) with computed tomography (CT) and PET with magnetic resonance imaging (MRI) in patients with biochemically known hyperparathyroidism; (2) compare the diagnostic performance of FCH PET/CT or PET/MRI with conventional morphological and functional imaging. A literature search until December 2019 was performed in the PubMed, Scopus and Web of Science databases, using the terms “choline” AND “PET” AND “hyperparathyroidism”. The search was conducted with and without the addition of filters (e.g., language: English only; type of article: original article; subjects: humans only) and selecting only articles published in the last 5 years. Twenty-three articles and 1112 patients were considered. Different FCH PET/CT acquisition protocols were adopted across the studies, using dynamic, early or delayed scans. FCH PET/CT proved more accurate than ultrasonography (US) or 99mTc-sestamibi single-photon emission tomography (SPET). PET/MRI also seemed to be more accurate than MRI alone in detecting benign parathyroid lesions. FCH PET/CT is more accurate than conventional morphological and functional imaging modalities (US or SPET) for the detection of benign parathyroid lesions. It could, therefore, be a reliable tool in both primary and recurrent hyperparathyroidism.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-020-01507-1