Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration

We investigated whether pre-existing diabetes, newly-diagnosed diabetes, and admission hyperglycemia were associated with COVID-19 severity independently from confounders. We retrospectively analyzed data on patients with COVID-19 hospitalized between February and April 2020 in an outbreak hospital...

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Published in:Diabetes research and clinical practice 2020-10, Vol.168, p.108374-108374, Article 108374
Main Authors: Fadini, Gian Paolo, Morieri, Mario Luca, Boscari, Federico, Fioretto, Paola, Maran, Alberto, Busetto, Luca, Bonora, Benedetta Maria, Selmin, Elisa, Arcidiacono, Gaetano, Pinelli, Silvia, Farnia, Filippo, Falaguasta, Daniele, Russo, Lucia, Voltan, Giacomo, Mazzocut, Sara, Costantini, Giorgia, Ghirardini, Francesca, Tresso, Silvia, Cattelan, Anna Maria, Vianello, Andrea, Avogaro, Angelo, Vettor, Roberto
Format: Article
Language:English
Subjects:
Age of Onset
Aged
Aged, 80 and over
Betacoronavirus - physiology
Blood Glucose - analysis
Blood Glucose - metabolism
Comorbidity
Coronavirus Infections - complications
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
Coronavirus Infections - therapy
COVID-19
Diabetes Complications - blood
Diabetes Complications - diagnosis
Diabetes Complications - epidemiology
Diabetes Complications - pathology
Diabetes Mellitus - blood
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
Diabetes Mellitus - therapy
Female
Humans
Hyperglycemia - complications
Hyperglycemia - diagnosis
Hyperglycemia - epidemiology
Hyperglycemia - therapy
Italy - epidemiology
Male
Mediation
Metabolism
Middle Aged
Observational
Pandemics
Patient Admission
Pneumonia, Viral - complications
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Pneumonia, Viral - therapy
Prediction
Prognosis
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Survival
Treatment Outcome
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Summary:We investigated whether pre-existing diabetes, newly-diagnosed diabetes, and admission hyperglycemia were associated with COVID-19 severity independently from confounders. We retrospectively analyzed data on patients with COVID-19 hospitalized between February and April 2020 in an outbreak hospital in North-East Italy. Pre-existing diabetes was defined by self-reported history, electronic medical records, or ongoing medications. Newly-diagnosed diabetes was defined by HbA1c and fasting glucose. The primary outcome was a composite of ICU admission or death. 413 subjects were included, 107 of whom (25.6%) had diabetes, including 21 newly-diagnosed. Patients with diabetes were older and had greater comorbidity burden. The primary outcome occurred in 37.4% of patients with diabetes compared to 20.3% in those without (RR 1.85; 95%C.I. 1.33–2.57; p 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108374