Nanostructured selenium-doped biphasic calcium phosphate with in situ incorporation of silver for antibacterial applications

Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (CaP) materials in diverse medical applications. In this study, the selenium-doped biphasic calcium phosphate nanoparticles (SeB-NPs) were first synthesized. Then, si...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.13738, Article 13738
Main Authors: Nie, Lei, Hou, Mengjuan, Wang, Tianwen, Sun, Meng, Hou, Ruixia
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Calcium phosphates
Cells, Cultured
Cholecystokinin
Escherichia coli - drug effects
Fourier analysis
Humans
Hydroxyapatites - chemistry
Hydroxyapatites - pharmacology
Infrared spectroscopy
Metal Nanoparticles - chemistry
Microbial Sensitivity Tests - methods
Microscopy, Electron, Transmission - methods
Nanoparticles
Nanostructures - chemistry
Osteoblasts
Particle Size
Photoelectron spectroscopy
Photoelectron Spectroscopy - methods
Raman spectroscopy
Selenium
Selenium - chemistry
Silver
Silver - chemistry
Spectrophotometry, Ultraviolet - methods
Spectroscopy, Fourier Transform Infrared - methods
Spectrum analysis
Staphylococcus aureus - drug effects
Transmission electron microscopy
X-ray diffraction
X-Ray Diffraction - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Selenium-doped nanostructure has been considered as an attractive approach to enhance the antibacterial activity of calcium phosphate (CaP) materials in diverse medical applications. In this study, the selenium-doped biphasic calcium phosphate nanoparticles (SeB-NPs) were first synthesized. Then, silver was in situ incorporated into SeB-NPs to obtain nanostructured composite nanoparticles ( SeB-NPs). Both SeB-NPs and SeB-NPs were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS), and Raman spectra. The results confirmed that the SeO was doped at the PO position and silver nanoparticles were deposited on the surface of SeB-NPs. Next, Transmission Electron Microscopy (TEM) analysis displayed that the prepared SeB-NPs had a needle-cluster-like morphology. CCK-8 analysis revealed SeB-NPs and SeB-NPs had good cytocompatibility with osteoblasts. The antibacterial activity of the prepared SeB-NPs was confirmed by using Gram-negative E. coli and Gram-positive S. aureus. The above results manifested the significance of the final SeB-NPs for biomedical applications.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70776-7