Pancreatic sarcoidosis mimicking neoplasia: Case report

•Involvement of the pancreas is exceedingly rare in sarcoidosis.•Pancreatitis in a patient with pulmonary sarcoidosis can be secondary to a sarcoid inflammatory process.•Pancreatic sarcoidosis can be discovered incidentally on radiography and may mimic neoplasia.•Pancreatic sarcoidosis can be found...

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Bibliographic Details
Published in:International journal of surgery case reports 2020-01, Vol.74, p.63-65
Main Authors: Chedid, Georges, Harb, Jad Gerges, Noureldine, Hussein A., Tayar, Claude, Nasser, Selim M., Sabbah, Nada Abbas
Format: Article
Language:English
Subjects:
Case report
Histopathology
Incidental
Pancreatic cancer
Pancreatic retention cyst
Sarcoidosis
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Summary:•Involvement of the pancreas is exceedingly rare in sarcoidosis.•Pancreatitis in a patient with pulmonary sarcoidosis can be secondary to a sarcoid inflammatory process.•Pancreatic sarcoidosis can be discovered incidentally on radiography and may mimic neoplasia.•Pancreatic sarcoidosis can be found concomitantly with more than one type of neoplastic lesion.•Histopathologic assessment is required for definitive diagnosis. Although sarcoidosis rarely involves the pancreas, such involvement may mimic pancreatic cancer. We herein report a case of pancreatic sarcoidosis giving rise to a cancer-mimicking retention cyst, concomitant with a neuroendocrine adenoma. A 47-year-old Caucasian male presented to follow-up for a benign-appearing cyst of the tail of the pancreas, detected incidentally on CT scan done for a urinary stone in 2017. He had been asymptomatic since his last presentation. The lesion was found to have increased in size from 1 cm to 3 cm in greater diameter. Yet, a CT angiography showed no evidence of invasion of surrounding organs, vessels, or lymph nodes. The patient had previous medical history of treated sarcoidosis, hypertension, recurrent nephrolithiasis, and gout. Due to the size increment a neoplastic cystic lesion was considered and distal pancreatectomy was performed. Pathologic examination revealed a retention cyst associated with chronic pancreatitis and the presence of non-caseating granulomas consistent with sarcoidosis. In addition, a neuroendocrine adenoma, and an adjacent focus of pancreatic intraepithelial neoplasia-1 and 2 were noted. Such presentations may be asymptomatic, as in this case, and a multidisciplinary workup is often required. Care must be taken to rule out pancreatic cancer. A possible relationship between pancreatic sarcoidosis and pancreatic cancer merits further study. The diagnosis of pancreatic sarcoidosis is difficult, and conclusive diagnosis requires histopathologic assessment.
ISSN:2210-2612
2210-2612
DOI:10.1016/j.ijscr.2020.07.070