Mitochondrial DNA control region variation in a population sample from Thailand

Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total of 170 different haplotypes were identified, of which 146 occurred only once (unique haplotypes). The dataset showed a random match probability of 0.87...

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Bibliographic Details
Published in:International journal of legal medicine 2020-09, Vol.134 (5), p.1563-1568
Main Authors: Sauer, Dirk Christopher, Naue, Jana, Immel, Uta-Dorothee, Lutz-Bonengel, Sabine
Format: Article
Language:English
Subjects:
Analysis of Variance
Asian Continental Ancestry Group - ethnology
Datasets
Datasets as Topic
DNA, Mitochondrial - analysis
Ethnic Groups - genetics
Female
Forensic Medicine
Gene sequencing
Genetic Variation
Genetics, Population
Hair - chemistry
Haplotypes
Humans
Locus Control Region
Male
Medical Law
Medicine
Medicine & Public Health
Mitochondrial DNA
Original
Original Article
Population genetics
Sequence Analysis, DNA
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Summary:Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total of 170 different haplotypes were identified, of which 146 occurred only once (unique haplotypes). The dataset showed a random match probability of 0.87% and a haplotype diversity of 0.9960. The samples were assigned to 85 different haplogroups with B5a, F1a1a, and M being the most frequent ones. Pairwise F ST -values between this and other Southeast and East Asian populations revealed significant but relatively low differences, indicating a close relation. Heteroplasmic positions were observed in 12.2% of hair samples confirming the frequent appearance of heteroplasmic positions in hairs. This dataset will complement existing data as an mtDNA reference for forensic investigations.
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-020-02303-2