SARS‐CoV‐2 infection in persons living with HIV: A single center prospective cohort

Information about severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in HIV‐infected individuals is scarce. In this prospective study, we included HIV (human immunodefeciency virus)‐infected individuals (people living with HIV [PLWHIV]) with confirmed SARS‐CoV‐2 infection and com...

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Bibliographic Details
Published in:Journal of Medical Virology 2021-02, Vol.93 (2), p.1145-1149
Main Authors: Maggiolo, Franco, Zoboli, Fabio, Arosio, Marco, Valenti, Daniela, Guarneri, Davide, Sangiorgio, Lorena, Ripamonti, Diego, Callegaro, Annapaola
Format: Article
Language:English
Subjects:
Age
Age composition
Age Distribution
Anosmia
Antiretroviral agents
Asymptomatic
CD4
CD4 antigen
CD4 Lymphocyte Count - statistics & numerical data
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
CNS
cohort
Comorbidity
Coronaviridae
Coronaviruses
Cough
COVID-19
COVID-19 - epidemiology
COVID-19 - mortality
COVID-19 - virology
co‐morbidities
Dyspnea
Epidemiology
Fatalities
Female
Fever
Health risks
HIV
HIV Infections - epidemiology
HIV Infections - virology
Human immunodeficiency virus
Humans
Immunosuppression
Infections
Male
Middle Aged
Morbidity
mortality
Olfaction disorders
Polymerase chain reaction
Prospective Studies
Respiration
Respiratory diseases
Reverse transcription
Risk analysis
Risk Factors
SARS‐CoV‐2
Serology
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Short Communication
Short Communications
Signs and symptoms
symptoms
Taste disorders
Viral diseases
Virology
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Summary:Information about severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection in HIV‐infected individuals is scarce. In this prospective study, we included HIV (human immunodefeciency virus)‐infected individuals (people living with HIV [PLWHIV]) with confirmed SARS‐CoV‐2 infection and compared them with PLWHIV negative for SARS‐CoV‐2. We compared 55 cases of SARS‐CoV‐2 infection with 69 asymptomatic PLWHIV negative for SARS‐CoV‐2 reverse transcription‐polymerase chain reaction and/or serology. There was no significant difference between SARS‐CoV‐2 positive or negative patients for age distribution, gender, time with HIV infection, nadir CD4‐cell counts, type and number of co‐morbidities, current CD4 and CD8 counts and type of anti‐HIV therapy. Positive patients presented with a median of three symptoms (interquartile range, 1‐3). Most common symptoms were fever (76%), dyspnea (35%), anosmia (29%) non‐productive cough (27%), fatigue 22%), and ageusia (20%). Ten patients (18%) were completely asymptomatic. Four (7.2%) subjects died of coronavirus disease 2019. Factors significantly (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26352