Self‐Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Applications

This Full Paper reports the formation of silver (Ag) NPs within spatially resolved two‐component hydrogel beads, which combine a low‐molecular‐weight gelator (LMWG) DBS‐CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed through in situ reduction of AgI, with the resulting nano...

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Bibliographic Details
Published in:Chemistry : a European journal 2020-07, Vol.26 (38), p.8452-8457
Main Authors: Piras, Carmen C., Mahon, Clare S., Smith, David K.
Format: Article
Language:English
Subjects:
Alginic acid
Antibacterial activity
antimicrobial
Antimicrobial agents
Beads
Calcium
Calcium alginate
Chemistry
gel
Gels
Hydrogels
Nanocomposites
nanoparticle
Nanoparticles
Orthopedics
Polymers
Pseudomonas aeruginosa
self-assembly
Silver
supramolecular chemistry
Vancomycin
Wound healing
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Summary:This Full Paper reports the formation of silver (Ag) NPs within spatially resolved two‐component hydrogel beads, which combine a low‐molecular‐weight gelator (LMWG) DBS‐CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed through in situ reduction of AgI, with the resulting nanoparticle‐loaded gels being characterised in detail. The antibacterial activity of the nanocomposite gel beads was tested against two drug‐resistant bacterial strains, often associated with hospital‐acquired infections: vancomycin‐resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa (PA14), and the AgNP‐loaded gels showed good antimicrobial properties against both types of bacteria. It is suggested that the gel bead format of these AgNP‐loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing. Hybrid gel beads loaded with silver nanoparticles show antimicrobial activity against drug‐resistant bacteria. Each component plays a unique role: the calcium alginate polymer gelator provides mechanical strength and enables shaping into beads, and the dibenzylidenesorbitol low‐molecular‐weight gelator gives control over AgNP formation within the beads.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202001349