The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an oppor...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2020-04, Vol.181 (2), p.236-249
Main Authors: Rood, Jennifer E., Coffey, Robert J., Demir, Emek, Ghosh, Sharmistha, Iacobuzio-Donahue, Christine A., Jané-Valbuena, Judit, Mazzilli, Sarah A., Pe’er, Dana, Tan, Kai, Aguilar, Ruben A., Babur, Ozgun, Boland, Genevieve, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Cerami, Ethan, Chang, Young Hwan, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Feng, Chun, Jaeyoung, Cisneros, Luis, Contrepois, Kevin, Creason, Allison L., Diskin, Sharon, Drewes, Julia, Eng, Jennifer, Erwin, Graham, Flaherty, Keith, Gao, Jianjiong, Gao, Vianne R., Giannakis, Marios, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Hacohen, Nir, Harris, Kathleen A., Hayashi, Akimasa, Herndon, John M., Huh, Won Jae, Ijaz, Heba, Izar, Benjamin, Johnson, Brett E., Kaestner, Klaus, Kim, Albert H., Kopytra, Mateusz, Kundaje, Anshul, Lau, Ken S., Lee, Hayan, Lenburg, Marc, Lim, Kian-Huat, Lin, Yiyun, Lively, Tracy, Longabaugh, William J.R., Ma, Cynthia X., Marks, Jeffrey, Masilionais, Ignas, McKinley, Eliot T., McMichael, Joshua F., Mosse, Yael, Ness, Reid, Nikolov, Milen, Oberdoerffer, Philipp, Offin, Michael, Olson, Anastasiya, Ossandon, Miguel, Polyak, Kornelia, Reid, Mary, Roy, Sudipta, Ryser, Marc D., Schrag, Deborah, Sears, Rosalie C., Shalek, Alex, Sheng, Jeff, Shoghi, Kooresh I., Sibley, Alexander B., Sorger, Peter K., Southard-Smith, Austin, Srivastava, Sudhir, Storm, Phillip, Sullivan, Ryan, Suvà, Mario, Thorsson, Vésteinn, Tran, Linh, Veis, Deborah J., Vossough, Arastoo, Wagle, Nikhil, Wang, Liang-Bo, West, Robert, Wu, Chi-yun, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Zhang, Mianlei, Zhang, Yantian, Zhou, Daniel Cui, Zhuang, Xiaowei
Format: Article
Language:English
Subjects:
Atlases as Topic
Cancer Moonshot
cancer transitions
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
data integration
data visualization
Genomics - methods
Human Tumor Atlas
Humans
metastasis
Neoplasms - metabolism
pre-cancer
Precision Medicine - methods
resistance
Single-Cell Analysis - methods
single-cell genomics
spatial genomics
spatial imaging
tumor
Tumor Microenvironment - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer. The Human Tumor Atlas Network outlines their ambitious plan to generate 3D, single-cell, multiparametric, and longitudinal maps of diverse tumor types.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2020.03.053