Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure

Highlights • Neonatal sustained and intermittent hypoxia exposure augments basal spontaneous carotid body and nTS excitability in vitro. • Neonatal sustained and intermittent hypoxia exposure attenuates in vitro carotid body sensitivity to acute hypoxia. • A disturbance in CB and nTS neural function...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2015-01, Vol.205, p.28-36
Main Authors: Mayer, C.A, Wilson, C.G, MacFarlane, P.M
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Carotid body
Carotid Body - physiopathology
Chronic intermittent hypoxia
Disease Models, Animal
Hypoxia - physiopathology
Male
Medical Education
nTS
Pulmonary/Respiratory
Rats
Rats, Inbred Lew
Solitary Nucleus - physiopathology
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Summary:Highlights • Neonatal sustained and intermittent hypoxia exposure augments basal spontaneous carotid body and nTS excitability in vitro. • Neonatal sustained and intermittent hypoxia exposure attenuates in vitro carotid body sensitivity to acute hypoxia. • A disturbance in CB and nTS neural function following neonatal sustained and intermittent hypoxia impairs respiratory responses to acute hypoxia.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2014.09.015