Regional Structure-Function in Cystic Fibrosis Lung Disease Using Hyperpolarized 129Xe and Ultrashort Echo Magnetic Resonance Imaging

Thomen discusses the study on the regional structure-function in cystic fibrosis (CF) lung disease using hyperpolarized 129 Xe and ultrashort echo magnetic resonance imaging. CF is a genetic disorder that exhibits a number of different structural pulmonary abnormalities such as mucus plugs (MP), bro...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2020-07, Vol.202 (2), p.290-292
Main Authors: Thomen, Robert P, Walkup, Laura L, Roach, David J, Higano, Nara, Schapiro, Andrew, Brody, Alan, Clancy, John P, Cleveland, Zackary I, Woods, Jason C
Format: Article
Language:English
Subjects:
Correspondence
Cystic fibrosis
Genetics
Magnetic resonance imaging
Radiation
Tomography
Online Access:Get full text
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Summary:Thomen discusses the study on the regional structure-function in cystic fibrosis (CF) lung disease using hyperpolarized 129 Xe and ultrashort echo magnetic resonance imaging. CF is a genetic disorder that exhibits a number of different structural pulmonary abnormalities such as mucus plugs (MP), bronchiectasis (BR) bronchial wall (BW) thickening, and consolidations (CNs), each of which contribute to abnormal ventilation via regional obstruction. Although structural imaging methods (generally X-ray computed tomography [CT]) can depict regional structural pathologies, the precise extent to which these structural abnormalities contribute to lung function decline is not well understood. They demonstrate that hyperpolarized (HP) gas magnetic resonance imaging (MRU can be combined with ultrashort echo (UTK) MRI (a radiation-free alternative to CT [1-3]) to quantity the relationships between individual regional pathologies and regional ventilation.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.202001-0031LE