A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients

We analysed data from 80 patients who tested positive for SARS‐CoV‐2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared agains...

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Bibliographic Details
Published in:International Journal of Immunogenetics 2020-08, Vol.47 (4), p.324-328
Main Authors: Poulton, Kay, Wright, Paul, Hughes, Pamela, Savic, Sinisa, Welberry Smith, Matthew, Guiver, Malcolm, Morton, Muir, Dellen, David, Tholouli, Eleni, Wynn, Robert, Clark, Brendan
Format: Article
Language:English
Subjects:
Alleles
Antigens
Betacoronavirus - immunology
case/control studies
Coronavirus Infections - immunology
Coronavirus Infections - pathology
COVID-19
disease association
disease association studies
Drb1 protein
Gene Frequency
Genetic Predisposition to Disease - genetics
genetics
histocompatibility
Histocompatibility antigen HLA
Histocompatibility Testing
Hla & Disease
HLA-A Antigens - genetics
HLA-B Antigens - genetics
HLA-C Antigens - genetics
HLA-DQ beta-Chains - genetics
HLA-DRB1 Chains - genetics
human leucocyte antigens
Humans
immune response
immunology
molecular
Organ Transplantation
Original
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
population
Ribonucleic acid
RNA
SARS-CoV-2
severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Transplant Recipients
Transplantation
Transplants & implants
virology
virus
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Description
Summary:We analysed data from 80 patients who tested positive for SARS‐CoV‐2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA‐ DQB1*06 (53% vs. 36%; p 
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12505