Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic

The world is witnessing a difficult time. The race of developing a new coronavirus (COVID-19) vaccine is becoming more urgent. Many preliminary studies on the pathophysiology of COVID-19 patients have provided some clues to treat this pandemic. However, no suitable treatment has found yet. Various s...

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Published in:Phytomedicine (Stuttgart) 2021-05, Vol.85, p.153277-153277, Article 153277
Main Authors: Kulyar, Muhammad Fakhar-e-Alam, Li, Rongrong, Mehmood, Khalid, Waqas, Muhammad, Li, Kun, Li, Jiakui
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants - pharmacology
Benzoquinones - pharmacology
Black seed
Coronavirus
Covid-19
COVID-19 Drug Treatment
Drug Evaluation, Preclinical
Humans
Immune System - drug effects
Immunomodulation
Molecular Docking Simulation
Nagella sativa
Nigella sativa - chemistry
Nigellidine
Oleanolic Acid - pharmacology
Pandemics
Plant Extracts - pharmacology
Review
SARS-CoV-2 - drug effects
Thymoquinone
α-hederin
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Summary:The world is witnessing a difficult time. The race of developing a new coronavirus (COVID-19) vaccine is becoming more urgent. Many preliminary studies on the pathophysiology of COVID-19 patients have provided some clues to treat this pandemic. However, no suitable treatment has found yet. Various symptoms of patients infected with COVID-19 indicated the importance of immune regulation in the human body. Severe cases admitted to the intensive care unit showed high level of pro-inflammatory cytokines which enhanced the disease severity. Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients is another critical factor of disease severity and mortality. So, Immune modulation is the only way of regulating immune system. Nigella sativa has been used for medicinal purposes for centuries. The components of this plant are known for its intense immune-regulatory, anti-inflammatory, and antioxidant benefits in obstructive respiratory disorders. A molecular docking study also gave evidences that N. sativa decelerates COVID-19 and might give the same or better results than the FDA approved drugs. The aim of this review was to investigate the possible immune-regulatory effects of N. sativa on COVID-19 pandemic. Our review found N. sativa's Thymoquinone, Nigellidine, and α-hederin can be a potential influencer in reinforcing the immune response on molecular grounds. [Display omitted] .
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2020.153277