A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk

Evidence on the causal link between plasma triglyceride (TG) levels and risk for cardiovascular disease (CVD) has recently emerged. Individuals with the metabolic syndrome have an increased risk for acquiring elevated TG levels later in life. Moreover, common DNA sequence variations in genes affecti...

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Bibliographic Details
Published in:Journal of clinical lipidology 2019-05, Vol.13 (3), p.492-501
Main Authors: Verbeek, Rutger, Oldoni, Federico, Surendran, R. Preethi, Zwinderman, Ailko H., Khaw, Kay T., Stroes, Erik S.G., Wareham, Nick J., Boekholdt, S. Matthijs, Dallinga-Thie, Geesje M.
Format: Article
Language:English
Subjects:
Adult
Aged
APOA5
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cohort Studies
Female
Genetic Predisposition to Disease - genetics
Humans
Hypertriglyceridemia - blood
Hypertriglyceridemia - genetics
Hypertriglyceridemia - metabolism
LPL
Male
Metabolic syndrome
Middle Aged
Polymorphism, Single Nucleotide
Risk Assessment
Triglycerides
Triglycerides - blood
Triglycerides - genetics
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Summary:Evidence on the causal link between plasma triglyceride (TG) levels and risk for cardiovascular disease (CVD) has recently emerged. Individuals with the metabolic syndrome have an increased risk for acquiring elevated TG levels later in life. Moreover, common DNA sequence variations in genes affecting TG levels identify individuals at risk for elevated plasma TG levels. We evaluated whether a 3-single nucleotide polymorphism (SNP) TG gene risk score (GRS) and a metabolic risk score (MetRS) both improved CVD risk prediction. A 3-SNP GRS and MetRS were generated in the EPIC-Norfolk cohort (n = 20,074) based on 3 SNPs in LPL and APOA5 or the number of Metabolic Syndrome criteria present (maximum 5), respectively. The associations between the 3-SNP GRS, MetRS, TG levels, and CVD risk were evaluated. The 3-SNP GRS and MetRS were both linearly associated with plasma TG levels, that is, +0.25 mmol/L [95% CI 0.22–0.27] per allele change (P 
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2019.02.005