Variants in ADRB1 and CYP2C9: Association with Response to Atenolol and Losartan in Marfan Syndrome

To test whether variants in ADRB1 and CYP2C9 genes identify subgroups of individuals with differential response to treatment for Marfan syndrome through analysis of data from a large, randomized trial. In a subset of 250 white, non-Hispanic participants with Marfan syndrome in a prior randomized tri...

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Bibliographic Details

Published in:	The Journal of pediatrics 2020-07, Vol.222, p.213-220.e5
Main Authors:	Van Driest, Sara L., Sleeper, Lynn A., Gelb, Bruce D., Morris, Shaine A., Dietz, Harry C., Forbus, Geoffrey A., Goldmuntz, Elizabeth, Hoskoppal, Arvind, James, Jeanne, Lee, Teresa M., Levine, Jami C., Li, Jennifer S., Loeys, Bart L., Markham, Larry W., Meester, Josephina A.N., Mital, Seema, Mosley, Jonathan D., Olson, Aaron K., Renard, Marjolijn, Shaffer, Christian M., Sharkey, Angela, Young, Luciana, Lacro, Ronald V., Roden, Dan M.
Format:	Article
Language:	eng
Subjects:	Adolescent Adrenergic beta-1 Receptor Antagonists - therapeutic use Adult angiotensin II receptor blocker Angiotensin II Type 1 Receptor Blockers - therapeutic use aortic root dissection Atenolol - therapeutic use beta-adrenergic receptor blocker Child Child, Preschool Cytochrome P-450 CYP2C9 - biosynthesis Cytochrome P-450 CYP2C9 - genetics DNA - genetics Female Follow-Up Studies Gene Expression Regulation Genotype Humans Infant Losartan - therapeutic use Male Marfan Syndrome - drug therapy Marfan Syndrome - genetics Marfan Syndrome - metabolism personalized medicine pharmacogenetics pharmacogenomics Receptors, Adrenergic, beta-1 - biosynthesis Receptors, Adrenergic, beta-1 - genetics Retrospective Studies Young Adult
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