Recent applications of chemometrics in one‐ and two‐dimensional chromatography

The proliferation of increasingly more sophisticated analytical separation systems, often incorporating increasingly more powerful detection techniques, such as high‐resolution mass spectrometry, causes an urgent need for highly efficient data‐analysis and optimization strategies. This is especially...

Full description

Saved in:
Bibliographic Details
Published in:Journal of separation science 2020-05, Vol.43 (9-10), p.1678-1727
Main Authors: Bos, Tijmen S., Knol, Wouter C., Molenaar, Stef R.A., Niezen, Leon E., Schoenmakers, Peter J., Somsen, Govert W., Pirok, Bob W.J.
Format: Article
Language:English
Subjects:
1D chromatography
2D chromatography
Chemometrics
Chromatography
Data analysis
data processing
Liquid Chromatography
Mass spectrometry
Optimization
Review
Separation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The proliferation of increasingly more sophisticated analytical separation systems, often incorporating increasingly more powerful detection techniques, such as high‐resolution mass spectrometry, causes an urgent need for highly efficient data‐analysis and optimization strategies. This is especially true for comprehensive two‐dimensional chromatography applied to the separation of very complex samples. In this contribution, the requirement for chemometric tools is explained and the latest developments in approaches for (pre‐)processing and analyzing data arising from one‐ and two‐dimensional chromatography systems are reviewed. The final part of this review focuses on the application of chemometrics for method development and optimization.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.202000011