Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions

To report population age-specific prevalence of core cerebrovascular disease lesions (infarctions, cerebral microbleeds, and white-matter hyperintensities detected with magnetic resonance imaging); estimate cut points for white-matter hyperintensity positivity; investigate sex differences in prevale...

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Bibliographic Details
Published in:	Mayo Clinic proceedings 2020-06, Vol.95 (6), p.1195-1205
Main Authors:	Graff-Radford, Jonathan, Aakre, Jeremiah A., Knopman, David S., Schwarz, Christopher G., Flemming, Kelly D., Rabinstein, Alejandro A., Gunter, Jeffrey L., Ward, Chadwick P., Zuk, Samantha M., Spychalla, A.J., Preboske, Gregory M., Petersen, Ronald C., Kantarci, Kejal, Huston, John, Jack, Clifford R., Mielke, Michelle M., Vemuri, Prashanthi
Format:	Article
Language:	eng
Subjects:	Age Aging Biomarkers Cerebrovascular disease Cerebrovascular diseases Cognitive ability Dementia Diagnostic imaging Epidemiology Magnetic resonance imaging Medical research Medicine, Experimental Population Studies Type 2 diabetes
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Summary:	To report population age-specific prevalence of core cerebrovascular disease lesions (infarctions, cerebral microbleeds, and white-matter hyperintensities detected with magnetic resonance imaging); estimate cut points for white-matter hyperintensity positivity; investigate sex differences in prevalence; and estimate prevalence of any core cerebrovascular disease features. Participants in the population-based Mayo Clinic Study of Aging aged 50 to 89 years underwent fluid-attenuated inversion recovery and T2* gradient-recalled echo magnetic resonance imaging to assess cerebrovascular disease between October 10, 2011, and September 29, 2017. We characterized each participant as having infarct, normal versus abnormal white-matter hyperintensity, cerebral microbleed, or a combination of lesions. Prevalence of cerebrovascular disease biomarkers was derived through adjustment for nonparticipation and standardization to the population of Olmsted County, Minnesota. Among 1462 participants without dementia (median [range] age, 68 [50 to 89] y; men, 52.7%), core cerebrovascular disease features increased with age. Prevalence (95% CI) of cerebral microbleeds was 13.6% (11.6%-15.6%); infarcts, 11.7% (9.7%-13.8%); and abnormal white-matter hyperintensity, 10.7% (8.7%-12.6%). Infarcts and cerebral microbleeds were more common among men. In contrast, abnormal white-matter hyperintensity was more common among women ages 60 to 79 y and men, ages 80 y and older. Prevalence of any core cerebrovascular disease feature determined by presence of at least one cerebrovascular disease feature increased from 9.5% (ages 50 to 59 y) to 73.8% (ages 80 to 89 y). Whereas this study focused on participants without dementia, the high prevalence of cerebrovascular disease imaging lesions in elderly persons makes assignment of clinical relevance to cognition and other downstream manifestations more probabilistic than deterministic.
ISSN:	0025-6196 1942-5546