One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles

2,5-Diaryltetrazoles are a diverse range of compounds of considerable interest within the field of photochemistry as a valuable precursor of the nitrile imine 1,3-dipole. Current literature approaches toward this heterocycle remain unsuitable for the practical synthesis of a library of these derivat...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-06, Vol.85 (11), p.7413-7423
Main Authors: Livingstone, Keith, Bertrand, Sophie, Jamieson, Craig
Format: Article
Language:English
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Summary:2,5-Diaryltetrazoles are a diverse range of compounds of considerable interest within the field of photochemistry as a valuable precursor of the nitrile imine 1,3-dipole. Current literature approaches toward this heterocycle remain unsuitable for the practical synthesis of a library of these derivatives. Herein, we disclose the development of a modular approach toward 2,5-diaryltetrazoles compatible with an array-type protocol, facilitated by a tandem Suzuki-hydrogenolysis approach.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c00807