A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003

To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. This is a cross-sectional study reviewing pediatric patients with...

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Bibliographic Details
Published in:The Journal of pediatrics 2020-09, Vol.224, p.30-36
Main Authors: Xiong, Xiaoli, Chua, Gilbert T., Chi, Shuiqing, Kwan, Mike Yat Wah, Sang Wong, Wilfred Hing, Zhou, Aifen, Shek, Chi Chiu, Tung, Keith T.S., Qin, Huan, Wong, Rosa S., Li, Xue, Chen, Peng, Li, Shuai, Chui, Celine S., Tso, Winnie W.Y., Ho, Marco H.K., Wong, Ian C.K., Chan, Godfrey C.F., Lau, Yu Lung, Wong, Kenneth K.Y., Chung, Patrick H.Y., Li, Hui, Tam, Paul K.H., Tang, Shao-tao, Ip, Patrick
Format: Article
Language:English
Subjects:
Adolescent
Asymptomatic Infections
Betacoronavirus
Child
Child, Preschool
children
China - epidemiology
Chinese
Coronavirus Infections - diagnosis
Coronavirus Infections - epidemiology
COVID-19
Cross-Sectional Studies
Female
Hong Kong
Hospitalization
Humans
Infant
Length of Stay
Male
Original
Pandemics
Pneumonia, Viral - diagnosis
Pneumonia, Viral - epidemiology
Retrospective Studies
SARS
SARS Virus
SARS-CoV-2
Severe Acute Respiratory Syndrome - diagnosis
Severe Acute Respiratory Syndrome - epidemiology
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Summary:To compare the clinical and laboratory features of severe acute respiratory syndrome 2003 (SARS) and coronavirus disease 2019 (COVID-19) in 2 Chinese pediatric cohorts, given that the causative pathogens and are biologically similar. This is a cross-sectional study reviewing pediatric patients with SARS (n = 43) and COVID-19 (n = 244) who were admitted to the Princess Margaret Hospital in Hong Kong and Wuhan Children's Hospital in Wuhan, respectively. Demographics, hospital length of stay, and clinical and laboratory features were compared. Overall, 97.7% of patients with SARS and 85.2% of patients with COVID-19 had epidemiologic associations with known cases. Significantly more patients with SARS developed fever, chills, myalgia, malaise, coryza, sore throat, sputum production, nausea, headache, and dizziness than patients with COVID-19. No patients with SARS were asymptomatic at the time of admission, whereas 29.1% and 20.9% of patients with COVID-19 were asymptomatic on admission and throughout their hospital stay, respectively. More patients with SARS required oxygen supplementation than patients with COVID-19 (18.6 vs 4.7%; P = .004). Only 1.6% of patients with COVID-19 and 2.3% of patients with SARS required mechanical ventilation. Leukopenia (37.2% vs 18.6%; P = .008), lymphopenia (95.4% vs 32.6%; P 
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2020.06.041