Influence of diabetes mellitus on the severity and fatality of SARS‐CoV‐2 (COVID‐19) infection

Aim To evaluate the influence of diabetes on the severity and fatality of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. Materials and Methods The medical records of 66 hospitalized coronavirus disease 2019 (COVID‐19) patients were collected and classified into non‐severe (m...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2020-10, Vol.22 (10), p.1907-1914
Main Authors: Wu, Jing, Zhang, Jingqi, Sun, Xiaohua, Wang, Lijuan, Xu, Yunfang, Zhang, Yuanyuan, Liu, Xingxiang, Dong, Chen
Format: Article
Language:English
Subjects:
Adult
Aged
Antidiabetics
China - epidemiology
Coronaviridae
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - mortality
COVID-19 - pathology
COVID-19 - therapy
Diabetes
Diabetes Complications - epidemiology
Diabetes Complications - mortality
Diabetes Complications - pathology
Diabetes mellitus
Diabetes Mellitus - epidemiology
Diabetes Mellitus - mortality
Diabetes Mellitus - pathology
Diabetes Mellitus - therapy
Fatalities
fatality
Female
Hospitalization - statistics & numerical data
Humans
Infections
Male
Medical records
Middle Aged
Original
Pandemics
SARS-CoV-2 - physiology
Severe acute respiratory syndrome coronavirus 2
severity
Severity of Illness Index
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Summary:Aim To evaluate the influence of diabetes on the severity and fatality of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. Materials and Methods The medical records of 66 hospitalized coronavirus disease 2019 (COVID‐19) patients were collected and classified into non‐severe (mild/moderate cases) and severe (severe/critical cases) groups. Logistic regression analysis was used to estimate the risk of severe COVID‐19 (severe/critical infection). In addition, a meta‐analysis including published studies reported the impact of diabetes on the severity and fatality of COVID‐19. The current study was conducted using fixed effects models. Results There were 22 diabetes and 44 non‐diabetes cases among the 66 hospitalized COVID‐19 patients. Seven patients with diabetes (31.82%) were diagnosed as severe COVID‐19 cases, which was significantly higher than that in the non‐diabetes group (4/44, 9.09%, P = .033). After adjustment for age and gender, diabetes was significantly associated with COVID‐19 severity (OR: 5.29, 95% CI: 1.07–26.02). A meta‐analysis further confirmed the positive association between diabetes and COVID‐19 severity (pooled OR = 2.58, 95% CI: 1.93–3.45). Moreover, the patients with diabetes infected with SARS‐CoV‐2 had a 2.95‐fold higher risk of fatality compared with those patients without diabetes (95% CI: 1.93–4.53). Conclusions Our findings provide new evidence that diabetes is associated with a higher risk of severity and fatality of COVID‐19. Therefore, intensive monitoring and antidiabetic therapy should be considered in patients with diabetes with SARS‐CoV‐2 infection.
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.14105